Volunteer for NIAID-funded clinical studies related to sexually transmitted diseases on ClinicalTrials.gov.
Some common STDs are curable, while others are incurable but treatable. All, however, are preventable. That’s why a team of researchers spread across multiple institutions and continents is working toward a clearer understanding of the way HIV and other STDs are acquired and spread. Their striking results have attracted the attention of international health organizations and could potentially influence public health policy.
Since the late 1990s, a team of researchers from the NIAID Laboratory of Immunoregulation (LIR), the Johns Hopkins Bloomberg School of Public Health, and the Rakai Health Sciences Program in Uganda has sought better ways to diagnose and prevent HIV, chlamydia, genital herpes, syphilis, human papillomavirus (HPV), and gonorrhea. A large portion of the team’s research has taken place in the Rakai district of Uganda, where a study of a group of 12,000 people has led to breakthroughs in STD diagnosis and prevention. The program is headed by Thomas Quinn, M.D., M.Sc., director of the Johns Hopkins Center for Global Health and chief of the International HIV/STD Section of LIR at NIAID.
In 2005, a Rakai study overseen by Ronald Gray, M.B.B.S., M.Sc., and Maria Wawer, M.D., M.H.S., both of Johns Hopkins, and David Serwadda, M.B.Ch.B., M.Med., M.P.H., of Makerere University College of Health Sciences, revealed a startling result: After surgical circumcision, heterosexual men in the Rakai cohort showed a 60 percent reduction in the rate of HIV infection compared to heterosexual male study participants who were not circumcised.
The results were so definitive that Dr. Quinn’s team halted the study and offered circumcision to the control group. This astounding proof of circumcision as an effective HIV prevention method was named the top medical breakthrough of 2007 by Time magazine. That same year, the World Health Organization and the Joint United Nations Programme on HIV/AIDS both endorsed male circumcision as an effective means of decreasing the spread of HIV.
The study’s success raised another question: Would circumcision have any secondary outcomes? The researchers decided to test their success against other common STDs, and the results were equally promising: Men circumcised at the beginning of the study had a 50-percent reduction in rates of genital ulcer disease predominately caused by genital herpes and a 30- to 35-percent reduction in rates of HPV, including the types of HPV that cause cancer. The benefits also extended to the wives of the circumcised men: a 50-percent reduction in rates of genital ulcer disease, as well as a dramatic reduction in other STDs such as trichomoniasis and bacterial vaginosis.
Dr. Quinn’s lab is also working to make chlamydia easier to diagnose and, as a result, easier to prevent among uninfected people. The typical method of diagnosing chlamydia among women is a pelvic exam in a physician’s office. But researchers in Dr. Quinn’s lab, in conjunction with Charlotte Gaydos, Dr.P.H., professor of infectious diseases at Johns Hopkins, helped to develop a method of chlamydia screening using either urine or a self-administered vaginal or penile swab that makes diagnosis more convenient and private.
The researchers are considering using the website to distribute newly developed tests for other STDs, including those that could be performed at home. Dr. Quinn and his team were among the first to demonstrate that such a non-invasive screening for STDs could extend public health efforts to control STDs beyond the hospital or physician’s office.
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Last Updated April 04, 2012