Prevention of Immune-Mediated Graft Rejection
The major goals of NIAID’s transplantation research program are:
- Understand the pathways whereby the immune system recognizes transplanted organs, tissues, and cells
- Characterize the cellular and molecular components of acute rejection and chronic graft failure
- Evaluate novel therapies for treating rejection and prolonging graft survival in preclinical models
- Develop and implement strategies for immune tolerance induction
- Conduct clinical trials of new therapies to improve graft survival, while minimizing the toxic side effects of immunosuppressive drugs