The Laboratory of Host Defenses (LHD) studies immune functions needed to fight infection and maintain health. LHD investigators study immune abnormalities that occur in patients with inherited immune system disorders that can lead to recurrent infections or autoimmune diseases.
The research program of the LHD Genetic Immunotherapy Section is developing gene therapy and stem cell transplantation approaches to the treatment of a variety of inherited primary immune deficiencies. The section’s bone marrow transplant program is focused on developing improved methods of stem cell transplantation using bone marrow, stem cells found in circulation, or cord blood from either a matched sibling or an unrelated donor. Because stem cell transplantation carries a significant risk of causing graft versus host disease (GVHD), a condition caused when the newly transplanted cells attack the transplant recipient’s body, LHD investigators are developing methods and treatments to prevent or treat acute and chronic GVHD. Investigators also are developing methods to induce immune tolerance in transplant recipients.
The following transplantation clinical study is actively recruiting participants:
Learn more about the Genetic Immunotherapy Section and the Laboratory of Host Defenses.
Last Updated July 20, 2011
Last Reviewed July 20, 2011