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Human Helminth Co-infections Clinical Trials Database

Title PI/Study Contact Conditions Age Groups Phase Recruitment Status Study Type

Immunological Consequences of Helminth and Mycobacterial Coinfection

Tom Nutman (E-mail)

Intestinal Helminth Infection; Filarial Infection

Child; Adult

 

Completed

Observational

The Effect of Schistosome and Soil-transmitted Helminth Infections on Malaria, Infection, Morbidity and Antibody Response Among School and Pre-school Children in Mwanza, Tanzania

Safari M Kinung’hi (E-mail)

Anaemia; Malaria; Hepatosplenomegaly

Child

 

Active, not recruiting

Interventional

Treatment of Helminth co-Infection: Short-Term Effects on HIV-1 Progression Markers and Immune Activation

Judd Walson (E-mail)

HIV infections; Helminthiasis

Adult; Senior

 

Completed

Interventional

Empiric Therapy of Helminth Co-Infection to Reduce HIV-1 Disease Progression

Judd Walson (E-mail)

HIV Infections; Helminthiasis

Adult; Senior

 

Active, not recruiting

Interventional

Helminth-Induced Immunomodula-tion Therapy (HINT) in Relapsing-Remitting Multiple Sclerosis

John O Fleming (E-mail)

Multiple Sclerosis

Adult

 

Recruiting

Interventional

Medical Implications of Coinfection With Malaria and Filariasis Parasites

Siddhartha Mahanty (E-mail)

Malaria; Filariasis

Child; Adult

 

Completed

Observational

Can Presumptive Antihelminthic Treatment Delay the Progression of HIV in ART-naїve Patients in Rural Africa?

Cornelia J. Staehelin (E-mail)

HIV; Helminthiasis; HIV infections

Adult; Senior

 

Recruiting

Interventional

Interaction Between HIV and Lymphatic Filariasis

Paul Simonsen (E-mail)

HIV infection; Lymphatic filariasis

Adult; Senior

 

Completed

Interventional

Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and Effect of Treatment

Diana Karanja (E-mail)

Anaemia; Schistosomiasis infection; Malaria; Iron deficiency

Child

 

Active, not recruiting

Observational

S. Japonicum and Pregnancy Outcomes

Jennifer Freidman (E-mail)

Schistosomiasis (Bilharziasis)

Child; Adult; Senior

II

Recruiting

Interventional

Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar

Peter DC Leutscher (E-mail)

Sexually transmitted infections; Schistosoma haemotobium

Child; Adult

 

Completed

Interventional

Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites

Amy Klion (E-mail)

Malaria; Filarial infection

Child; Adult

 

Completed

Observational

Relative Efficacy of Two Regimens of Anti-Helminthic Treatment

Mohammad M Alam (E-mail)

Helminthiasis

Child

 

Not yet recruiting

Interventional

Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis

Tom Nutman (E-mail)

Filarial infection; HIV infections

Adult; Senior

 

Recruiting

Observational

The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and Re-Infection Along Lake Victoria, Uganda

Edridah M Tukahebwa (E-mail)

Schistosomiasis; Malaria

Child; Adult; Senior

 

Completed

Interventional

Deworming Against Tuberculosis

Ebba Abate (E-mail)

Tuberculosis

Adult

 

Recruiting

Interventional

Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART-naive Patients in Kenya

Judd Walson (E-mail)

HIV infections; Human Immunodeficiency Virus; Malaria; Plasmodium falciparum; Diarrhea

Adult; Senior

 

Enrolling by invitation

Observational

Trichuris Suis Ova Therapy for Relapsing Multiple Sclerosis - A Safety Study

Per S Sørensen (E-mail)

Relapsing Multiple Sclerosis

Adult

II

Not yet recruiting

Interventional

Epidemiology and Control of Mansonella Perstans Infection in Uganda

Asanta M Asio (E-mail)

Mansonelliasis; Pruritus; Lymphoedema; Abdominal pains

Child; Adult; Senior

 

Completed

Interventional

Randomised Controlled Clinical Trials of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctiv-itis

John Britton (E-mail)

Rhinitis, allergic, perennial; Hayfever; Allergy

Adult; Senior

 

Completed

Interventional

Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma

John Britton (E-mail)

Asthma

Adult; Senior

 

Completed

Interventional

Intestinal helminth infections and schistosomiasis and their relation to human immunodeficiency virus-1 (HIV-1) incidence, disease progression and immunology in Mbeya Region, Tanzania - epidemiology component

Elmar Saathoff (E-mail)

Human immunodeficiency virus-1 (HIV-1) infection; Helminth infections

 

 

Recruiting

Interventional

Intestinal helminth infections suppress atopy and incidence of malaria and this suppression is reversible by antihelminthic treatment

About the Immunospin Scientific Programme

Maria Yazdanbakhsh (E-mail)

Intestinal helminths; Malaria; Allergy

 

 

Recruiting

 

Effect of repeated four-monthly albendazole treatments on malaria in pre-school children living in communities endemic for Ascaris lumbricoides: a double-blind placebo-controlled randomised trial

Celia Holland (E-mail)

 

 

 

Completed

 

The impact of helminths on the response to immunisation and on the incidence of infection and disease in childhood in Uganda

Alison Elliott (E-mail)

 

 

 

 

 

Impact of maternal and early infant geohelminth infections on vaccine immunity and the development of allergic inflammatory disease

Philip Cooper (E-mail)

Intestinal helminth infections; Vaccine immunity; Allergy

Child

 

Completed

Observational

Studies of Immune Responses to Orally Administered Vaccines in Developing Country

Qadri Firdausi (E-mail)

Cholera; Typhoid

Child; Adult

I; II

Recruiting

Interventional

Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-Sensitivity

John T. Croese (E-mail)

Celiac disease

Adult; Senior

II

Completed

Interventional

A community trial for visceral leishmaniasis Dinesh Mondal (E-mail) Visceral leishmaniasis Child; Adult
  Recruiting Interventional
Worm Infestation and Child Health in Zimbabwe (Zimworms) Takafira Mduluza, Ph.D.

Malaria; Polyparasitism; Coccidiosis; Protozoan Infections

Child
  Completed Interventional
Worms and human immunodeficiency virus (HIV) interaction study—Epidemiology component Elmar Saathof (E-mail)

HIV-1 infection; helminth infections


  Completed Observational
Worms for Immune Regulation of Multiple Sclerosis (WIRMS) Cris Constantinescu (E-mail)

Multiple sclerosis, relapsing-remitting

Adult
II Recruiting Interventional
Lake Victoria Island Intervention Study on Worms and Allergy-Related Diseases LaVIISWA Alison Elliott Worm infections and their effects on general health and on allergy-related conditions Adult; Child   Recruiting Interventional
Impact on Physical Fitness and Cognitive Ability in School Children From Southern Cote D’Ivoire After Treatment Against Intestinal Helminth Infections Juerg Utzinger Neglected tropical diseases (soil-transmitted helminth and schistosomiasis infections); Malaria Child   Recruiting Interventional
Effect of Filarial Infection on Immune Relapses in Latent Tuberculosis Tom Nutman (Email) Tuberculosis; Filariasis Adult   Not yet recruiting Observational
A Study of Co-infections of HIV-1 and Schistosoma Mansoni and its Impact on Praziquantel Treatment Outcomes Humphrey D. Mazigo Anemia; Intestinal helminthiasis; Intestinal schistosomiasis; HIV-1; Hematological diseases; Opportunistic infections Adult   Not yet recruiting Interventional
Trichuris Suis Ova (TSO)in Recurrent Remittent Multiple Sclerosis and Clinically Isolated Syndrome (TRIOMS) Berit Rosche (Email) Multiple sclerosis Adult II Recruiting Interventional
Trichuris Suis Ova in Autism Spectrum Disorders (TSO) Eric Hollander, M.D. Autism Adult I Recruiting Interventional
Mucosal Immunity of Ulcerative Colitis Patients Undergoing Therapy With Trichuris Suis Ova (MUCUS) Michael A.
Poles, M.D., Ph.D.;
P’ng Loke, M.D.
Ulcerative colitis Adult   Recruiting Interventional

 

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Last Updated March 12, 2012