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International Collaborative Network for the Study of Human Helminth Co-infections

The International Collaborative Network for the Study of Human Helminth Co-infections was formed to ensure that clinical studies examining helminth co-infections have the resources necessary to provide definitive answers that can inform public health policy related to helminth control programs.

There is growing evidence from both laboratory and clinical studies that helminth infections can modulate the immune response to parenterally administered vaccines, infectious diseases, autoimmune diseases, and allergic diatheses. Human clinical studies have yielded conflicting results on the effect of helminth infections on acquisition and severity of many non-helminth infections and other disorders. More recently, studies on filarial infections and schistosomiasis have pointed to systemic (and often chronic) helminth infections as modulators of the responses to secondary infections.

As a result, a group of investigators performing clinical trials with the influence of helminths on other infectious diseases and non-infectious disorders (for example, allergic and autoimmune diseases) has put together a database of those performing such trials and will work to ensure more definitive answers related to understanding the relationship between helminth infections and other viral, bacterial, and protozoan pathogens, as well as to allergic and autoimmune diseases. In addition, the network will establish collective guidelines for data collection and tissue sampling and storage.

The international collaborative network will address the following issues:

  • State of ongoing studies in human helminth co-infections
  • Development of guidelines for data collection and tissue sampling
  • Development of information and tissue repositories for data sharing

The network will work toward the following goals:

  • Summarize and discuss available data on helminth co-infections in humans
  • Expand the consortium of clinical researchers and available resources for collaborative studies
  • Foster the development of multicenter protocols to study human helminth co-infections

Ongoing Clinical Trials

See the Human Helminth Co-infections Clinical Trials Database for information on current clinical trials.

Or, see a list of investigators performing clinical studies on helminth co-infections (Excel).

Join the Network

NIAID has established the Helminth Co-infections ListServ to facilitate the exchange of information and encourage researcher collaboration.

Users can register for, unsubscribe from, and post messages to the list at the Archives of Helminth Co-infection.

For information on how to use the listserv, see Instructions for General Users.

Selected Publications

The following are lists of publications related to human helminth infections and concomitant infections or other disease processes:


Thomas B. Nutman, M.D.
Chief, Helminth Immunology Section
Laboratory of Parasitic Diseases, NIAID
Bethesda, Maryland

Zvi Bentwich, M.D.
Head, Center for Emerging Tropical Diseases and AIDS
Department of Virology, Ben Gurion University
Beer Sheba, Israel  

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Last Updated March 12, 2012