Skip Navigation
Skip Website Tools

Contact Info

Email: prpl@mail.cc.nih.gov
Call toll free: 800-411-1222
(TTY 866-411-1010)
Se habla español.
More contact info

Online Screener

Healthy people can help us better understand, treat, and prevent diseases. Complete an online screener if you want to volunteer for a clinical research study.

NIAID HIV and Emerging Infectious Diseases Program

Skip Content Marketing
  • Share this:
  • submit to facebook
  • Tweet it
  • submit to reddit
  • submit to StumbleUpon
  • submit to Google +

Healthy Volunteer Studies

Studies of healthy volunteers are crucial to the understanding and treatment of diseases. They provide a baseline for measuring the extent of disease and provide important information about the safety and effectiveness of various treatments. The National Institutes of Health (NIH) houses the nation’s most renowned biomedical research institutions. The following clinical research studies are being conducted by NIAID and the NIH Clinical Center in Bethesda, Maryland:

Phase 1 Study of Safety and Immunogenicity of AD4-H5-VTN in AD4 Seronegative Volunteers

(SAMOSA – Protocol #11-I-0259)

We will recruit 68 subjects (and up to 68 of their intimate contacts) who are healthy individuals between 18 and 49 years of age; if you have an intimate contact participating, they must be between the ages of 18 and 65. Volunteers must be in good general health, and be willing to receive a live influenza vaccine. Volunteers must also be willing to spend 7 days hospitalized at the NIH, and to return for at least six visits up to 12 months following vaccination. Intimate contacts must come to the NIH for two visits. Volunteers will be compensated.

A Phase I, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of AVI-7100 in Healthy Subjects

(AVI-7100, Protocol # 13-I-0029)

We will recruit 40 individuals for the single dose cohort, then 24 individuals for a multi-dose cohort later. We are looking for healthy volunteers between the ages of 18-60. The primary goal of this study is to evaluate a new anti-viral drug called AVI-7100 that might have activity against influenza virus. This drug is being studied and has not been approved by the Food and Drug Administration (FDA). This drug is given through a vein (IV), and is not like any of the drugs currently available for influenza. The drug binds to the genetic material of the virus and may keep a person who takes the drug from having a more serious case of the flu. Volunteers will be compensated.

Phase 1 Study of Safety and Immunogenicity of Intranasal AD4-H5-VTN in AD4 Seronegative Volunteers

(NAAN, Protocol 13-I-0081)

The purpose of this study is to test an experimental vaccine to see if it is safe. The vaccine uses a live adenovirus as a carrier (or transporter). We hope that the adenovirus carrier will help the vaccine stimulate an immune response. An immune response is the body’s release of cells and substances that protect the body from infection and foreign matter. Another important goal is to see whether different routes (ways) of giving the vaccine cause different immune responses. We also want to see if the adenovirus in the vaccine is contagious or spreads to others. Adenoviruses are naturally occurring viruses that typically cause symptoms of a cold or conjunctivitis (a superficial eye infection). If we find a safe dose (amount) of adenovirus virus to stimulate the immune system, we hope to use this as a carrier for future vaccines to help prevent diseases such as malaria or HIV. Volunteers will be compensated.​

The Influence of Cobicistat or Ritonavir on Dabigatran Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(P-3 – Protocol #13-CC-0160)

We will recruit 16 subjects who are HIV-negative, healthy individuals between 18 and 70 years of age. Volunteers must be in good general health, and be willing to take the medications dabigatran (Pradaxa®, an anti-coagulant) and ritonavir (an HIV medication.)

After completion of the first 16 subjects, an additional 16 subjects will be recruited to take dabigatran with cobicistat (also an HIV medication.) Those volunteers who successfully completed the ritonavir portion of the study may also be considered to participate in the second arm of the study, if they wish. Each arm of the study requires seven visits in approximately a 54-day period. Four of those visits will last approximately one hour; three of those visits will last approximately 12 hours. Participants must provide their own transportation to the NIH. Volunteers will be compensated.​

Phase I Study of Safety and Immunogenicity of Ad4-HIV Vaccine Vectors in Healthy Volunteers

(NACHO, Protocol 14-I-0011)

The purpose of this study is to test experimental HIV vaccines to see if they are safe. HIV (human immunodeficiency virus) is the virus that causes AIDS (acquired immune deficiency syndrome). The vaccines use a live adenovirus as a carrier (or transporter). Adenoviruses are naturally occurring viruses that typically cause symptoms of a cold or conjunctivitis (a superficial eye infection). We hope that the adenovirus carrier will help the vaccines stimulate an immune response against HIV. An immune response is the body’s release of cells and substances that protect the body from infection and foreign matter. Another important goal is to see whether different ways of giving the vaccines cause different immune responses. We also want to see if the adenovirus in the vaccines is contagious or spreads to others. The study vaccine will not expose you to HIV infection. Volunteers will be compensated.​

A Phase 1 Randomized, Double-Blind, Placebo Controlled, Dose-Escalation Study to Evaluate the Safety and Immunogenicity of Prime-Boost VSV Ebola Vaccine in Healthy Adults

(VSV EBOLA – Protocol #15-I-0001)

The NIH is conducting a research study of VSV ZEBOV (BPSC1001), an anti-Ebola vaccine that has shown promise in animal studies. This is an experimental vaccine and we need to study it further to see if it is safe. We also need to see how it affects peoples’ immune system. This is the first time this vaccine will be used in humans. This vaccine has not been approved by the US Food and Drug Administration (FDA). You will be randomly assigned (in a manner similar to picking a number out of a hat) to receive the vaccine or the placebo. The placebo is a saline solution that has no measurable effect on the body. There are 3 doses of vaccine that will be tested in this study. In each dose level, 10 of 13 people will receive the vaccine and 3 people will receive the placebo. Neither you nor your doctors will know whether you have been given the vaccine, or the placebo. The pharmacy staff will know which drug you are taking. We need you to return to the Clinical Center on Days 3, 7, 14, 28, 31, 35, 42, 56, 84, 180, and 365.

A total of 39 individuals are expected to participate in this study. There are about 13 visits required in a one-year period. Volunteers will be compensated.

back to top

Last Updated October 08, 2014