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Volunteer for a Herpes Vaccine Research Study

The study is testing the safety of a vaccine for herpes simplex virus-2 (HSV-2). In the United States, HSV-2 affects approximately 16 percent of persons aged 14 to 49. HSV-2 genital infection increases the risk of getting HIV or giving it to someone else. This virus can cause severe disease in people with immature or compromised immune systems. No vaccine is currently available.

Who can participate?

You may be eligible if you:

  • Are 18 to 40 years old
  • Are healthy or  have been infected with the herpes simplex virus
  • Are willing to use birth control

Participants will be assigned to one of three groups: (1) people who have been infected with HSV-1 and HSV-2, (2) people who have been infected only with HSV-1, and (3) people who have not been infected with either HSV-1 or HSV-2.

What does the study involve?

To determine if you are eligible to participate, you will need to visit the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, for two screening visits. Eligible participants will receive three vaccine injections over six months. Doctors will continue to monitor participants’ responses to the study vaccine for six months following the last injection.

Where is the study taking place?

The study is being conducted at the Warren Grant Magnuson Clinical Center (Building 10) at NIH. The NIH campus is accessible by car and public transportation.

How much does it cost?

There is no charge to participate in this research study. All study-related medical care and procedures are provided free of charge.

Will I receive payment?

Yes, you will be compensated for your participation in the study.

How do I find out more or volunteer?

If you are interested in volunteering for this study, go to the study’s confidential online questionnaire or contact:

Office of Patient Recruitment, NIH Clinical Center
Toll free: 1-800-411-1222 (reference 13-I-0172)
TTY: 1-866-411-1010 Se habla español
Office hours: 8 a.m.-3:30 p.m. ET

To learn more about this study (trial ID: NCT01915212), visit and read some frequently asked questions.

Last Updated September 04, 2013

Last Reviewed September 04, 2013