- Hugh Auchincloss, M.D., Principal Deputy Director, Acting Director
- Jill R. Harper, Ph.D., Deputy Director for Science Management and Director, Office of Science Management and Operations
- H. Clifford Lane, M.D., Deputy Director for Clinical Research and Special Projects
- Kimberly M. Barasch, Staff Assistant to the Director
- Patricia L. Conrad, Special Assistant to the Director
- Gregory K. Folkers, M.S., M.P.H.,Chief of Staff
- Sharon M. Gilles, Special Assistant to the Deputy Director
- David M. Morens, M.D., Senior Scientific Advisor
- Ian D. Simon, Ph.D., Senior Advisor to the Director
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