Clinical Core Services Laboratory at the Integrated Research Facility

Major Areas of Research

  • Molecular biology
    • DNA/RNA high-throughput extraction
    • Validated quantitative PCR (qPCR) assays
    • DNA/protein microarray analysis
    • Robotics (DNA/RNA extraction, plaque, microneuts, and ELISA)
  • Immunology
    • Immunophenotyping/flow cytometry
    • Cell sorting
    • Cytokine profiling
    • Immunofluorescence analysis
  • Study support
    • High containment automation
      • Sample registration via barcoding
      • High-throughput clinical pathology instrumentation
      • Tecan robot plaque assays
      • High-throughput flow cytometry analysis
    • Animal prescreening
    • Blood, body fluid, and tissue processing
    • Post-study viral assays
    • Central viral repository and inventory (FreezerPro)
    • Biosafety level (BSL)-3 and BSL-4 mentoring

Program Description

The Clinical Core Services Laboratory provides a full service core for immunology, clinical pathology, virology, high-containment training, and agent-specific assays required for monitoring animals in infectious disease studies. In addition, the Clinical Core Services Laboratory routinely performs assay optimization and ruggedization for high-throughput analysis of a wide variety of in vivo and in vitro studies involving high-consequence pathogens.

Processing virus-infected samples for flow cytometry analysis in the BSL-4.​

Processing virus-infected samples for flow cytometry analysis in the BSL-4.​

Credit
NIAID

Scientists preparing samples for plaque assay utilizing the EVOware robotics platform.

Scientists preparing samples for plaque assay utilizing the EVOware robotics platform.

Credit
NIAID

 

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