Staff Scientist, Cell Biology Section, Laboratory of Viral Diseases

Job Announcement Description

This opportunity is for a staff scientist position in the Cellular Biology Section (CBS) of the Laboratory of Viral Diseases (LVD) in the Division of Intramural Research (DIR) at the National Institute of Allergy and Infectious Diseases (NIAID). The CBS is extending basic understanding of host/virus interactions in multiple experimental systems. The CBS studies mechanisms of influenza A virus (IAV) evolution, antigenic variation in viral glycoproteins, immunodominance in B-cell and antibody responses to IAV infection and vaccination, and mechanisms of antiviral antibody effector functions—all of critical importance to the development of a universal influenza vaccine.  The CBS is extending these studies to deepen the understanding of antibody recognition of SARS-CoV-2 virions and infected cells.

The staff scientist will have broad responsibilities in managing research activities in the CBS and will develop and lead independent research projects in host-virus interactions under the direction of the principal investigator. These responsibilities include:

  • Generating and characterizing recombinant influenza viruses and coronaviruses
  • Developing novel assays for measuring viral infectivity and antibody neutralization
  • Generating antiviral monoclonal antibodies
  • Generating modified versions of monoclonal antibodies by genetic engineering
  • Mapping antibody epitopes by generating and characterizing viral escape mutants
  • Increasing the understanding of antibody mediated antiviral immunity
  • Supervising, training, and mentoring junior research staff
  • Leading independent research projects and teamwork with lab
  • Writing scientific papers and presenting data at conferences

Preferred Criteria:

  • Ph.D. in virology
  • Eight or more years of postdoctoral research with demonstrated scientific productivity (first author papers, coauthored papers, etc.)
  • Expertise with:
    • influenza virus biology
    • generating and characterizing recombinant influenza viruses
    • mouse models of influenza infection, immunization, and immunity
    • next generation sequencing of viruses
    • in vitro virus neutralizations assays and other aspects of antibody interactions with viruses
    • antibody gene isolation, cloning, and genetic modification
    • antibody purification and chemical modification
    • flow cytometry
    • confocal microscopy
  • Strong oral and written communication skills (documented by first author publications and oral presentations at conferences)
  • Excellent people skills, including successful interactions/collaborations with other laboratories and demonstrated ability to supervise and mentor junior scientists

To Apply

Interested candidates should send their curriculum vitae (CV), bibliography, and a one- to two-page statement on their background and interests in the position to amy.collins@nih.gov by October 13, 2020.

The Department of Health and Human Services, National Institutes of Health, and NIAID are equal opportunity employers dedicated to diversity, equity, and inclusion.

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