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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Coronaviruses
Older Adult (65+)
13 Results

Coronaviruses and Immunodeficiency

Study of the Immune Response to and Safety Profile of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

Currently, people with immune disorders fall outside of guidance for COVID-19 vaccination, as they are typically excluded from vaccine trials.

Coronaviruses

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

A study to learn how coronavirus affects different organs of the body and the function of the body's immune system.

Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines

The primary objectives of this study are to evaluate the safety and reactogenicity of delayed heterologous or homologous vaccine doses after Emergency Use Authorization (EUA)-dosed vaccines and to evaluate the breadth of the humoral immune responses of heterologous and homologous delayed boost re

Drug Treatment Study of Individuals With Mild COVID-19

This NIAID research study focuses on an experimental drug which may help treat COVID-19 by supporting the immune system.

Genetics of COVID-19 Susceptibility and Manifestations

The goal of this study is to learn more about the genetic contributions to the severity of disease in COVID-19. We hope to use this information to develop therapies to reduce the severity of symptoms of COVID-19 in some people.

Outpatient Treatment With Anti-Coronavirus Immunoglobulin (OTAC)

A research study testing an experimental COVID-19 treatment called anti-coronavirus hyperimmune intravenous immunoglobulin (hIVIG).

Study of How COVID-19 Affects Blood Cells and the Immune System

A study about how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Tratamiento ambulatorio con inmunoglobulina anticoronavirus (Outpatient Treatment with Anti-Coronavirus Immunoglobulin, OTAC)

Un estudio de investigación que prueba un tratamiento contra el COVID-19 en fase de investigación conocido como concentrado de inmunoglobulinas de administración intravenosa hiperinmunitarias (hIVIG) anticoronaviral.

Coronaviruses and Allergic Diseases

Assess the Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose

Randomized, placebo-controlled, crossover study to assess risk of recurrence of allergic reactions in individuals who had an immediate systemic allergic reaction after 1st dose of an mRNA COVID-19 vaccine and aiming to explore the underlying mechanism(s) of these reactions.

Coronaviruses and Flu (Influenza)

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

Are you an NIH staff member? If you have some time and have an interest in helping researchers make discoveries about COVID-19 and influenza, we need you!

We are interested in learning about long-term immunity in people who receive COVID-19 and/or flu vaccines.