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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Adult (18 to 64)
99 Results

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

Researchers at the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) seek healthy volunteers for a study looking at how common antibiotics affect the trillions of good microbes that live on and in our body, also known as our microbiome.

Allergic Diseases and Eczema (Atopic Dermatitis)

Online Survey About Eczema

This 10- to 20-minute survey is available for patients with eczema or parents of patients with eczema.  These questions will help us learn more about patient experiences to improve current research and guide future research. 

Arthritis

Rheumatoid Arthritis Studies

NIAID is committed to advancing the understanding of how and why autoimmune diseases such as rheumatoid arthritis occur.

Asthma

Airway Temperature (RATE)

Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an increase in tissue temperature in airway mucosa during asthma exacerbation.

Lung-Resident Memory Th2 Cells in Asthma

Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype.

Registry for Asthma Characterization and Recruitment 2 (RACR2)

There is a need for people to take part in research studies to learn more about diseases and how to treat them.

Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study) (SEARCH)

This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit.

Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics (ACE)

This protocol describes a single site mechanistic study to investigate microRNAs (miRNAs) that are differentially expressed in the airway epithelium of patients with asthma at baseline and in response to allergen challenge.

Autoimmune Diseases

EPIC Study

The primary objective of this NIAID study is to further characterize the natural history of idiopathic CD4 lymphocytopenia (ICL).

Chronic Granulomatous Disease (CGD)

Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.

Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

To learn more about when and why IBD may develop in some people with primary immune dysregulation.

Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995

This study will determine the long term medical condition and daily functioning of participants with CGD after a transplant and if possible, compare these results to participants who do not undergo a transplant.

Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease

To see if RFA is a safe and effective treatment for CGD-related liver abscesses.

Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease

This study is a prospective non-controlled, non-randomized Phase I/II clinical trial to assess the safety, feasibility and efficacy of cellular gene therapy in patients with chronic granulomatous disease.

Use of G-CSF to Obtain Blood Cell Precursors

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.

Chronic Granulomatous Disease (CGD) and Hyper-Immunoglobulin M (Hyper-IgM) Syndromes and Primary Immune Deficiency Diseases (PIDDs) and Wiskott-Aldrich Syndrome (WAS) and X-Linked Agammaglobulinemia (XLA) and X-Linked Lymphoproliferative Disease (XLP)

Participation in a Research Registry for Immune Disorders

To collect data on people with primary immune deficiency disorders.

Coronaviruses and Immunodeficiency

Study of the Immune Response to and Safety Profile of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

Currently, people with immune disorders fall outside of guidance for COVID-19 vaccination, as they are typically excluded from vaccine trials.

Coronaviruses

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Booster Effects with Autoimmune Treatments in Patients with Poor Response to Initial COVID-19 Vaccine

This is a national study that will compare the immune response to additional COVID‐19 vaccine doses in participants with autoimmune disease who did not mount an adequate response to the initial vaccination regimen.

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

A study to learn how coronavirus affects different organs of the body and the function of the body's immune system.

COVID-19-Recovered Specimen Collection Research Study

The NIAID Vaccine Research Center is looking for volunteers who are recovered from COVID-19 infection to donate blood for a research study.

Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines

The primary objectives of this study are to evaluate the safety and reactogenicity of delayed heterologous or homologous vaccine doses after Emergency Use Authorization (EUA)-dosed vaccines and to evaluate the breadth of the humoral immune responses of heterologous and homologous delayed boost re

Drug Treatment Study of Individuals With Mild COVID-19

This NIAID research study focuses on an experimental drug which may help treat COVID-19 by supporting the immune system.

Coronaviruses and Allergic Diseases

Assess the Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose

Randomized, placebo-controlled, crossover study to assess risk of recurrence of allergic reactions in individuals who had an immediate systemic allergic reaction after 1st dose of an mRNA COVID-19 vaccine and aiming to explore the underlying mechanism(s) of these reactions.