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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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HIV and Emerging Infectious Diseases
HIV/AIDS
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HIV/AIDS and Sexually Transmitted Diseases

APOLLO Study

We are studying the effects of GARDASIL 9 vaccination in people with ICL, which stands for idiopathic CD4 T cell lymphocytopenia. People with ICL get more human papillomavirus (HPV)-related diseases than people without ICL. HPV-related diseases include skin and genital warts and a variety of genital and anal precancerous lesions and cancers. These diseases are also more severe and harder to treat in people with ICL.

HIV/AIDS

CLOTRx Healthy Volunteer Study

People infected with HIV take drugs called antiretrovirals to keep the amount of HIV in their bodies low as well as anticoagulants to treat or prevent blood clots. This study will help gain a better understanding of how antiretrovirals and oral anticoagulants interact with each other.

Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults (REPRIEVE)

People infected with HIV are at risk for cardiovascular disease (CVD). This study will evaluate the use of pitavastatin to reduce the risk of CVD in adults infected with HIV who are on antiretroviral therapy (ART).

LTNP Study

A small group of people who are HIV positive remain healthy for long periods of time without medications. These Long-Term Non-Progressors have properties within their immune systems that control the virus and can help researchers determine how their immune systems control HIV disease.

PANDORA Study

This study will look for the development of IRIS (Immune Reconstitution Inflammatory Syndrome), a condition that can happen in patients who are infected with HIV, after they begin treatment with antiretroviral therapy (ART).

PIPPIN Study

The NIH is conducting a research study for people living with HIV and on HIV medications whose CD4 t-cell count is >100 but <350, with an undetectable HIV viral load.

Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa (HVTN702)

This study will evaluate the preventive vaccine efficacy, safety, and tolerability of the ALVAC-HIV vaccine + Bivalent Subtype C gp120 protein adjuvanted with MF59 in HIV-seronegative South African adults over 24 months from enrollment.

RPHI Study

Determining how the immune system of some patients is able to control HIV is felt to be a very important step for designing vaccines and therapies for HIV.

Safety and Efficacy Study of Injectable Cabotegravir Compared to Daily Oral Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC), For Pre-Exposure Prophylaxis in HIV-Uninfected Cisgender Men and Transgender Women Who Have Sex With Men

This study will evaluate the safety and efficacy of the injectable drug cabotegravir (CAB LA), for pre-exposure prophylaxis (PrEP) in HIV-uninfected cisgender men and transgender women who have sex with men (MSM and TGW).

WINGS Healthy Volunteer Study

The purpose of the study is to test HIV vaccines to see if they are safe. It is not possible to get HIV through participating in the study. Vaccines are used to create resistance to a disease, or to prevent infection. The study vaccines will use a live adenovirus, the type of virus that typically causes cold symptoms. We hope that this adenovirus will help to stimulate an immune response against HIV.

YODA Healthy Volunteer Study

In this study, we will look at whether rifapentine and isoniazid affect blood levels of a commonly used antiretroviral called tenofovir alafenamide, or TAF. The United States Food and Drug Administration (FDA) has approved rifapentine and isoniazid for treating TB.

Infectious Diseases and HIV/AIDS and Sexually Transmitted Diseases

Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (NEPTUNE)

We are asking you to join this study because you have had multiple outbreaks of warts and/or lesions caused by human papillomavirus (HPV). Medicine and surgery are not always effective to treat these outbreaks. We want to follow your HPV outbreaks over a long period of time to better understand how HPV infects the body and causes disease.