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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Laboratory of Infectious Diseases Clinical Research
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Coronaviruses and Flu (Influenza)

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

Are you an NIH staff member? If you have some time and have an interest in helping researchers make discoveries about COVID-19 and influenza, we need you!

We are interested in learning about long-term immunity in people who receive COVID-19 and/or flu vaccines.

Flu (Influenza)

Evaluating the Safety and Efficacy of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza

The purpose of this study is to evaluate whether IVIG can reduce the severity and duration of flu in people who are hospitalized with the flu.

Influenza in People With Normal and Weakened Immune Systems

This study will evaluate how the immune system responds to influenza infection and compare how the infection differs in patients with a weakened immune system versus those with a healthy immune system.

Natural History of Systemic and Nasal Mucosal Immunity after Influenza Vaccination in a Pediatric Population

The purpose of this research is to help NIAID researchers understand what happens in kids’ immune systems after receiving a flu vaccine. Researchers are enrolling children who will be receiving the seasonal flu vaccine.

Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of the Safety and Immunogenicity of BPL-1357, A BPL-Inactivated, Whole-Virus, Universal Influenza Vaccine

Researchers at the National Institutes of Health (NIH) are studying a new influenza (flu) vaccine that may protect against different flu strains. The study aims to learn more about the safety of this flu vaccine.

Respiratory Virus Hospitalization Study (FLU 003 Plus)

The purpose of this observational study is to describe the characteristics and outcomes over a 60-day follow-up period of participants with influenza virus infection (including influenza A subtypes such as H3N2 and 2009 H1N1, or influenza B), or a targeted non-influenza respiratory virus, who are hospitalized with severe illness and/or complication in geographically diverse locations.

Screening Healthy Volunteers for Influenza Challenge Studies

If you are healthy, have some time, and have an interest in helping researchers make discoveries about influenza (the flu), we need you for a screening study. The screening is used to determine eligibility for future studies that will help researchers learn more about the development and course of the flu virus.

Fungal Diseases

Cryptococcosis Study

This NIAID study is investigating why some people who are healthy and have normal immune function become infected with cryptococcosis.

Infectious Diseases

Phase 1 Study of the Safety and Immunogenicity of an Epstein-Barr virus (EBV) gp350- Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection

EBV is a herpesvirus that causes mono, technically known as “infectious mononucleosis.” EBV infects roughly 9 out of every 10 people worldwide. This vaccine contains one component of EBV called glycoprotein 350.