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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Coronaviruses
18 Results

Coronaviruses and Immunodeficiency

Study of the Immune Response to and Safety Profile of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

Currently, people with immune disorders fall outside of guidance for COVID-19 vaccination, as they are typically excluded from vaccine trials.

Coronaviruses

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

ACTIV-3—Therapeutics for Inpatients With COVID-19 (TICO)

The main purpose of NIAID's TICO is to learn if new treatments are safe and can help people in the hospital with COVID-19 get better and go home faster.

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Booster Effects with Autoimmune Treatments in Patients with Poor Response to Initial COVID-19 Vaccine

This is a national study that will compare the immune response to additional COVID‐19 vaccine doses in participants with autoimmune disease who did not mount an adequate response to the initial vaccination regimen.

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

A study to learn how coronavirus affects different organs of the body and the function of the body's immune system.

COVID-19-Recovered Specimen Collection Research Study

The NIAID Vaccine Research Center is looking for volunteers who are recovered from COVID-19 infection to donate blood for a research study.

Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines

The primary objectives of this study are to evaluate the safety and reactogenicity of delayed heterologous or homologous vaccine doses after Emergency Use Authorization (EUA)-dosed vaccines and to evaluate the breadth of the humoral immune responses of heterologous and homologous delayed boost re

Drug Treatment Study for Outpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in outpatients. Participants in the study will receive an experimental therapy or a placebo.

Drug Treatment Study of Individuals With Mild COVID-19

This NIAID research study focuses on an experimental drug which may help treat COVID-19 by supporting the immune system.

Genetics of COVID-19 Susceptibility and Manifestations

The goal of this study is to learn more about the genetic contributions to the severity of disease in COVID-19. We hope to use this information to develop therapies to reduce the severity of symptoms of COVID-19 in some people.

Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

The primary objectives of this study are to evaluate the short- and long-term health outcomes of SARS-CoV-2 infection in children, including multisystem inflammatory syndrome in children (MIS-C), and to characterize the immunologic pathways associated with different disease presentations and outcomes.

Study of How COVID-19 Affects Blood Cells and the Immune System

A study about how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Vaccine and Monoclonal Antibody Studies for the Prevention of COVID-19

The COVID-19 Prevention Network (CoVPN) is conducting studies to find safe and effective vaccines and monoclonal antibodies for (SARS-CoV-2), the virus that causes COVID-19.

Coronaviruses and Flu (Influenza)

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

Are you an NIH staff member? If you have some time and have an interest in helping researchers make discoveries about COVID-19 and influenza, we need you!

We are interested in learning about long-term immunity in people who receive COVID-19 and/or flu vaccines.

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

This study evaluates the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and also investigates whether prior SARS-CoV-2 infection may change that response.

Coronaviruses and Allergic Diseases

Systemic Allergic Reactions to SARS-CoV-2 Vaccination

Now that COVID vaccines have been approved for children this research is being expanded to determine whether highly allergic children or children with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely