Find a Clinical Trial

See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

Showing results filtered by:
Clear All
Coronaviruses
23 Results

Coronaviruses

Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up (PECOS)

This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population, including coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C), and characterize the immune response associated with these clinical presentations.

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Booster Effects with Autoimmune Treatments in Patients with Poor Response to Initial COVID-19 Vaccine

This is a national study that will compare the immune response to additional COVID‐19 vaccine doses in participants with autoimmune disease who did not mount an adequate response to the initial vaccination regimen.

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

A study to learn how coronavirus affects different organs of the body and the function of the body's immune system.

COVID-19-Recovered Specimen Collection Research Study

The NIAID Vaccine Research Center is looking for volunteers who are recovered from COVID-19 infection to donate blood for a research study.

Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines

The primary objectives of this study are to evaluate the safety and reactogenicity of delayed heterologous or homologous vaccine doses after Emergency Use Authorization (EUA)-dosed vaccines and to evaluate the breadth of the humoral immune responses of heterologous and homologous delayed boost re

Drug Treatment Study for Outpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in outpatients. Participants in the study will receive an experimental therapy or a placebo.

Drug Treatment Study of Individuals With Mild COVID-19

This NIAID research study focuses on an experimental drug which may help treat COVID-19 by supporting the immune system.

Genetics of COVID-19 Susceptibility and Manifestations

The goal of this study is to learn more about the genetic contributions to the severity of disease in COVID-19. We hope to use this information to develop therapies to reduce the severity of symptoms of COVID-19 in some people.

Outpatient Treatment With Anti-Coronavirus Immunoglobulin (OTAC)

A research study testing an experimental COVID-19 treatment called anti-coronavirus hyperimmune intravenous immunoglobulin (hIVIG).

Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

The primary objectives of this study are to evaluate the short- and long-term health outcomes of SARS-CoV-2 infection in children, including multisystem inflammatory syndrome in children (MIS-C), and to characterize the immunologic pathways associated with different disease presentations and outcomes.

Study of How COVID-19 Affects Blood Cells and the Immune System

A study about how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Terapia para pacientes graves ingresados con COVID-19 (ACTIV-3b Therapeutics for Severely Ill Patients with COVID-19 [TESICO])

Este estudio prueba el uso de tratamientos estándar más dos fármacos en fase de investigación para ayudar a las personas ingresadas en el hospital a recuperarse de problemas respiratorios graves por la COVID-19.

Therapeutics for Severely Ill Inpatients With COVID-19 (ACTIV-3b TESICO)

This study tests the use of standard treatments plus two investigational drugs to help people in the hospital recover from severe COVID-19 breathing problems.

Tratamiento ambulatorio con inmunoglobulina anticoronavirus (Outpatient Treatment with Anti-Coronavirus Immunoglobulin, OTAC)

Un estudio de investigación que prueba un tratamiento contra el COVID-19 en fase de investigación conocido como concentrado de inmunoglobulinas de administración intravenosa hiperinmunitarias (hIVIG) anticoronaviral.

Vaccine and Monoclonal Antibody Studies for the Prevention of COVID-19

The COVID-19 Prevention Network (CoVPN) is conducting studies to find safe and effective vaccines and monoclonal antibodies for (SARS-CoV-2), the virus that causes COVID-19.

Coronaviruses and Immunodeficiency

Study of the Immune Response to and Safety Profile of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

Currently, people with immune disorders fall outside of guidance for COVID-19 vaccination, as they are typically excluded from vaccine trials.

Coronaviruses and Allergic Diseases

Assess the Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose

Randomized, placebo-controlled, crossover study to assess risk of recurrence of allergic reactions in individuals who had an immediate systemic allergic reaction after 1st dose of an mRNA COVID-19 vaccine and aiming to explore the underlying mechanism(s) of these reactions.

Systemic Allergic Reactions to SARS-CoV-2 Vaccination

Now that COVID vaccines have been approved for children this research is being expanded to determine whether highly allergic children or children with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely

Coronaviruses and Flu (Influenza)

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

Are you an NIH staff member? If you have some time and have an interest in helping researchers make discoveries about COVID-19 and influenza, we need you!

We are interested in learning about long-term immunity in people who receive COVID-19 and/or flu vaccines.

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

This study evaluates the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and also investigates whether prior SARS-CoV-2 infection may change that response.