Find a Clinical Trial

See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Autoimmune Diseases and Immunodeficiency

NIAID Centralized Sequencing Protocol

This study serves as a centralized sequencing protocol for NIH human subjects research studies to facilitate standardization and consolidate accrual of genotype and phenotype data for participating programs.

Chronic Granulomatous Disease (CGD)

Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.

Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

To learn more about when and why IBD may develop in some people with primary immune dysregulation.

Use of G-CSF to Obtain Blood Cell Precursors

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.

Coronaviruses

COVID-19-Recovered Specimen Collection Research Study

The NIAID Vaccine Research Center is looking for volunteers who are recovered from COVID-19 infection to donate blood for a research study.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Coronaviruses and Flu (Influenza)

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

This study evaluates the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and also investigates whether prior SARS-CoV-2 infection may change that response.

Eczema (Atopic Dermatitis)

Natural History of Diseases Associated With Allergic Inflammation- Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways

Atopic dermatitis, commonly called eczema, is a common condition in children who have allergy-related diseases, including asthma. Researchers are interested in studying both individuals with atopic dermatitis and their close relatives (parents and children) to better understand how allergy-related diseases develop and progress.

Flu (Influenza)

Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine, VRCFLUNPF099-00-VP, in Healthy Adults

The flu is a common viral infection that can be deadly for certain people. Vaccines against flu have been developed to teach the body to prevent or fight the infection. A new vaccine may help the body to make an immune response to H1 flu, a flu strain that infects humans.

Influenza in People With Normal and Weakened Immune Systems

This study will evaluate how the immune system responds to influenza infection and compare how the infection differs in patients with a weakened immune system versus those with a healthy immune system.

Food Allergy

Early Peanut Introduction- Translation to Clinical Practice (EPI)

The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step toward prevention of food allergy. However, because that finding was from a clinical trial in a very select population, there are several major questions that must be answered in order to implement these findings into clinical practice without causing more harm than good. The goal of this project is to answer critical questions so that the potential of these recent findings can be realized.

Natural History and Genetics of Food Allergy and Related Conditions

About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.

Fungal Diseases

Evaluation and Follow-up of Patients With Cryptococcosis

This 5-year study will follow the course of disease in previously healthy patients with cryptococcosis who developed the disease for no identifiable reason.

Natural History of Individuals With Immune System Problems That Lead to Fungal Infections

The immune system is made up of special cells, tissues, and organs that fight infections. Problems with this system may lead to frequent, severe, or unusual fungal infections. These infections are often difficult to treat. Researchers want to collect blood and tissue samples from people who have unusual, persistent or severe fungal infections or immune problems that increase the risk of these infections.

Studies of Disorders With Increased Susceptibility to Fungal Infections

Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast.

HIV/AIDS

CLOTRx Healthy Volunteer Study

People infected with HIV take drugs called antiretrovirals to keep the amount of HIV in their bodies low as well as anticoagulants to treat or prevent blood clots. This study will help gain a better understanding of how antiretrovirals and oral anticoagulants interact with each other.

Help End HIV - Red Ribbon Registry

HIV remains a major health issue globally and within the United States. Recent audience research found that many Americans are not aware that HIV is still a health issue in the U.S., are unsure if they might be vulnerable to exposure, and do not know if there is a cure.

Safety and Efficacy Study of Injectable Cabotegravir Compared to Daily Oral Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC), For Pre-Exposure Prophylaxis in HIV-Uninfected Cisgender Men and Transgender Women Who Have Sex With Men

This study will evaluate the safety and efficacy of the injectable drug cabotegravir (CAB LA), for pre-exposure prophylaxis (PrEP) in HIV-uninfected cisgender men and transgender women who have sex with men (MSM and TGW).

WINGS Healthy Volunteer Study

The purpose of the study is to test HIV vaccines to see if they are safe. It is not possible to get HIV through participating in the study. Vaccines are used to create resistance to a disease, or to prevent infection. The study vaccines will use a live adenovirus, the type of virus that typically causes cold symptoms. We hope that this adenovirus will help to stimulate an immune response against HIV.

YODA Healthy Volunteer Study

In this study, we will look at whether rifapentine and isoniazid affect blood levels of a commonly used antiretroviral called tenofovir alafenamide, or TAF. The United States Food and Drug Administration (FDA) has approved rifapentine and isoniazid for treating TB.

Infectious Diseases

Phase 1 Study of the Safety and Immunogenicity of an Epstein-Barr virus (EBV) gp350- Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection

EBV is a herpesvirus that causes mono, technically known as “infectious mononucleosis.” EBV infects roughly 9 out of every 10 people worldwide. This vaccine contains one component of EBV called glycoprotein 350.

Lyme Disease (Borreliosis)

A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations

This study will determine whether patients who have been infected with the Lyme bacteria, Borrelia burgdorferi, and treated with antibiotics still have the bacteria alive inside them and whether it is causing their symptoms.

Other

Apheresis and Specimen Collection Procedures to Obtain Plasma, Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens for Research Studies

This study collects specimens from volunteers for use in studies by NIAID's Vaccine Research Center. A number of different types of specimens or samples can be collected, including blood, urine, body fluids or secretions, skin swabs, or skin biopsies.

Apheresis Procedures to Obtain Plasma or PBMCs and Other Specimens for Research Studies

This study collects specimens from volunteers for use in studies by NIAID's Vaccine Research Center. A number of different types of specimens or samples can be collected, including blood, urine, body fluids or secretions, skin swabs, or skin biopsies. The samples are used for medical research, including the study of HIV, hepatitis, and other diseases; immune system responses, such as responses to vaccinations or infections; and for research on vaccine development.

Screening Volunteers for Clinical Trials

The National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health needs healthy volunteers for vaccine clinical trials. These trials will allow researchers to study vaccines and injection devices.