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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Maryland
63 Results

Autoimmune Diseases

EPIC Study

The primary objective of this NIAID study is to further characterize the natural history of idiopathic CD4 lymphocytopenia (ICL).

Autoimmune Diseases and Immunodeficiency

NIAID Centralized Sequencing Protocol

This study serves as a centralized sequencing protocol for NIH human subjects research studies to facilitate standardization and consolidate accrual of genotype and phenotype data for participating programs.

Chronic Granulomatous Disease (CGD)

Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.

Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

To learn more about when and why IBD may develop in some people with primary immune dysregulation.

Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995

This study will determine the long term medical condition and daily functioning of participants with CGD after a transplant and if possible, compare these results to participants who do not undergo a transplant.

Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease

To see if RFA is a safe and effective treatment for CGD-related liver abscesses.

Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease

This study is a prospective non-controlled, non-randomized Phase I/II clinical trial to assess the safety, feasibility and efficacy of cellular gene therapy in patients with chronic granulomatous disease.

Use of G-CSF to Obtain Blood Cell Precursors

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.

Chronic Granulomatous Disease (CGD) and Hyper-Immunoglobulin M (Hyper-IgM) Syndromes and Primary Immune Deficiency Diseases (PIDDs) and Wiskott-Aldrich Syndrome (WAS) and X-Linked Agammaglobulinemia (XLA) and X-Linked Lymphoproliferative Disease (XLP)

Participation in a Research Registry for Immune Disorders

To collect data on people with primary immune deficiency disorders.

Coronaviruses

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

A study to learn how coronavirus affects different organs of the body and the function of the body's immune system.

COVID-19-Recovered Specimen Collection Research Study

The NIAID Vaccine Research Center is looking for volunteers who are recovered from COVID-19 infection to donate blood for a research study.

Drug Treatment Study of Individuals With Mild COVID-19

This NIAID research study focuses on an experimental drug which may help treat COVID-19 by supporting the immune system.

Outpatient Treatment With Anti-Coronavirus Immunoglobulin (OTAC)

A research study testing an experimental COVID-19 treatment called anti-coronavirus hyperimmune intravenous immunoglobulin (hIVIG).

Study of How COVID-19 Affects Blood Cells and the Immune System

A study about how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Tratamiento ambulatorio con inmunoglobulina anticoronavirus (Outpatient Treatment with Anti-Coronavirus Immunoglobulin, OTAC)

Un estudio de investigación que prueba un tratamiento contra el COVID-19 en fase de investigación conocido como concentrado de inmunoglobulinas de administración intravenosa hiperinmunitarias (hIVIG) anticoronaviral.

Coronaviruses and Flu (Influenza)

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

This study evaluates the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and also investigates whether prior SARS-CoV-2 infection may change that response.

Eczema (Atopic Dermatitis)

Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis

Researchers want to see if introducing bacteria, R mucosa, from healthy skin onto the skin of someone with atopic dermatitis helps treat the disease.

Natural History of Diseases Associated With Allergic Inflammation- Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways

Atopic dermatitis, commonly called eczema, is a common condition in children who have allergy-related diseases, including asthma. Researchers are interested in studying both individuals with atopic dermatitis and their close relatives (parents and children) to better understand how allergy-related diseases develop and progress.

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection

The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder with skeletal, vascular, and connective tissue manifestations. This study enrolls patients and families with a confirmed or suspected diagnosis of HIES syndrome for extensive phenotypic and genotypic study as well as disease management.

Study of Therapeutic Bacteria for Atopic Dermatitis

This study tests a new approach to therapy using live bacteria (also called a probiotic). NIAID researchers will introduce the bacteria Roseomonas mucosa from healthy skin onto the skin of someone with atopic dermatitis to see if it helps to treat the disease.

Flu (Influenza)

Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine, VRCFLUNPF099-00-VP, in Healthy Adults

The flu is a common viral infection that can be deadly for certain people. Vaccines against flu have been developed to teach the body to prevent or fight the infection. A new vaccine may help the body to make an immune response to H1 flu, a flu strain that infects humans.

Evaluating the Safety and Efficacy of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza

The purpose of this study is to evaluate whether IVIG can reduce the severity and duration of flu in people who are hospitalized with the flu.

Influenza in People With Normal and Weakened Immune Systems

This study will evaluate how the immune system responds to influenza infection and compare how the infection differs in patients with a weakened immune system versus those with a healthy immune system.

Food Allergy

Early Peanut Introduction- Translation to Clinical Practice (EPI)

The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step toward prevention of food allergy. However, because that finding was from a clinical trial in a very select population, there are several major questions that must be answered in order to implement these findings into clinical practice without causing more harm than good. The goal of this project is to answer critical questions so that the potential of these recent findings can be realized.