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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

Researchers at the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) seek healthy volunteers for a study looking at how common antibiotics affect the trillions of good microbes that live on and in our body, also known as our microbiome.

Arthritis

Rheumatoid Arthritis Studies

NIAID is committed to advancing the understanding of how and why autoimmune diseases such as rheumatoid arthritis occur.

Autoimmune Diseases and Immunodeficiency

NIAID Centralized Sequencing Protocol

This study serves as a centralized sequencing protocol for NIH human subjects research studies to facilitate standardization and consolidate accrual of genotype and phenotype data for participating programs.

Coronaviruses

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Booster Effects with Autoimmune Treatments in Patients with Poor Response to Initial COVID-19 Vaccine

This is a national study that will compare the immune response to additional COVID‐19 vaccine doses in participants with autoimmune disease who did not mount an adequate response to the initial vaccination regimen.

Genetics of COVID-19 Susceptibility and Manifestations

The goal of this study is to learn more about the genetic contributions to the severity of disease in COVID-19. We hope to use this information to develop therapies to reduce the severity of symptoms of COVID-19 in some people.

Study of How COVID-19 Affects Blood Cells and the Immune System

A study about how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Coronaviruses and Allergic Diseases

Assess the Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose

Randomized, placebo-controlled, crossover study to assess risk of recurrence of allergic reactions in individuals who had an immediate systemic allergic reaction after 1st dose of an mRNA COVID-19 vaccine and aiming to explore the underlying mechanism(s) of these reactions.

Systemic Allergic Reactions to SARS-CoV-2 Vaccination

Now that COVID vaccines have been approved for children this research is being expanded to determine whether highly allergic children or children with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely

Coronaviruses and Flu (Influenza)

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

This study evaluates the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and also investigates whether prior SARS-CoV-2 infection may change that response.

Diabetes

TrialNet Pathway to Prevention of Type 1 Diabetes

The goal of this study is to enhance understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes.

Type 1 Diabetes Extension Study (T1DES)

The goal of this study is to further the understanding of the immunologic mechanisms underlying maintenance and loss of beta cell function by evaluating the relationship between longitudinal changes in beta cell function and changes over time in biomarkers known to be associated with a response to immune modulating treatments used in prior clinical trials.

Eczema (Atopic Dermatitis)

Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis

Researchers want to see if introducing bacteria, R mucosa, from healthy skin onto the skin of someone with atopic dermatitis helps treat the disease.

Effect of Dupilumab on the Host-Microbe Interface in Atopic Dermatitis

Research teams across the United States are conducting this clinical trial to assess the effect of dupilumab in treating the skin of adults with chronic moderate to severe atopic dermatitis or eczema.

Etiology of Eczema Herpeticum (EH)

Those with atopic dermatitis, also called eczema, may have complications from skin infections such as eczema herpeticum after herpes simplex virus (HSV) infection. The purpose of this study is to determine why some individuals with atopic dermatitis are at higher risk for recurrent skin infections with HSV.

Natural History of Diseases Associated With Allergic Inflammation- Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways

Atopic dermatitis, commonly called eczema, is a common condition in children who have allergy-related diseases, including asthma. Researchers are interested in studying both individuals with atopic dermatitis and their close relatives (parents and children) to better understand how allergy-related diseases develop and progress.

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection

The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder with skeletal, vascular, and connective tissue manifestations. This study enrolls patients and families with a confirmed or suspected diagnosis of HIES syndrome for extensive phenotypic and genotypic study as well as disease management.

Study of Therapeutic Bacteria for Atopic Dermatitis

This study tests a new approach to therapy using live bacteria (also called a probiotic). NIAID researchers will introduce the bacteria Roseomonas mucosa from healthy skin onto the skin of someone with atopic dermatitis to see if it helps to treat the disease.

Targeted Microbiome Transplant in Atopic Dermatitis

The purpose of this study is to examine the safety and effectiveness of a new therapy, commensal lotion containing infection-fighting bacteria, on decreasing or eliminating the infection-causing bacteria found on the skin of atopic dermatitis patients.

Flu (Influenza)

Age and Response to Flu Vaccines

The study will be designed as a prospective surveillance of the immune response to seasonal influenza vaccination in 240 healthy children and adults ages 9 and over.

Analysis of Bone Marrow and Blood B Cell Immune Responses to Influenza Vaccination

The study is designed to assess the humoral response to influenza vaccination and the longevity of humoral immunity to influenza vaccination in healthy adults.

Evaluating the Safety and Efficacy of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza

The purpose of this study is to evaluate whether IVIG can reduce the severity and duration of flu in people who are hospitalized with the flu.

Evaluation of Human Immune Responses to Influenza Virus Vaccination in Healthy Volunteers

This is an open label single arm observational study of longitudinal immunologic responses to influenza vaccine in healthy adults.