Find a Clinical Trial

See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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19 Results

Allergic Diseases and Eczema (Atopic Dermatitis)

Online Survey About Eczema

This 10- to 20-minute survey is available for patients with eczema or parents of patients with eczema.  These questions will help us learn more about patient experiences to improve current research and guide future research. 

Arthritis

Rheumatoid Arthritis Studies

NIAID is committed to advancing the understanding of how and why autoimmune diseases such as rheumatoid arthritis occur.

Asthma

A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children (MUPPITS-2)

The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.

Cockroach Immunotherapy in Children and Adolescents (CRITICAL)

Scientific evidence has shown that, over the past two decades, the combination of cockroach allergy and cockroach exposure is one of the most important factors contributing to the dramatic increase in asthma morbidity seen in inner city children with asthma.

Lung-Resident Memory Th2 Cells in Asthma

Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype.

Preventing Asthma in High Risk Kids (PARK)

This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE) for two years will prevent the progression to childhood asthma, as reflected by a reduction in the prevalence of active asthma in the Final 12 months during 2 year observation period off study drug.

Registry for Asthma Characterization and Recruitment 2 (RACR2)

There is a need for people to take part in research studies to learn more about diseases and how to treat them.

Chronic Granulomatous Disease (CGD)

Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995

This study will determine the long term medical condition and daily functioning of participants with CGD after a transplant and if possible, compare these results to participants who do not undergo a transplant.

Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease

This study is a prospective non-controlled, non-randomized Phase I/II clinical trial to assess the safety, feasibility and efficacy of cellular gene therapy in patients with chronic granulomatous disease.

Coronaviruses

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Diabetes

Type 1 Diabetes Extension Study (T1DES)

The goal of this study is to further the understanding of the immunologic mechanisms underlying maintenance and loss of beta cell function by evaluating the relationship between longitudinal changes in beta cell function and changes over time in biomarkers known to be associated with a response to immune modulating treatments used in prior clinical trials.

Flu (Influenza)

Respiratory Virus Hospitalization Study (FLU 003 Plus)

The purpose of this observational study is to describe the characteristics and outcomes over a 60-day follow-up period of participants with influenza virus infection (including influenza A subtypes such as H3N2 and 2009 H1N1, or influenza B), or a targeted non-influenza respiratory virus, who are hospitalized with severe illness and/or complication in geographically diverse locations.

Food Allergy

Early Peanut Introduction- Translation to Clinical Practice (EPI)

The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step toward prevention of food allergy. However, because that finding was from a clinical trial in a very select population, there are several major questions that must be answered in order to implement these findings into clinical practice without causing more harm than good. The goal of this project is to answer critical questions so that the potential of these recent findings can be realized.

Six Food vs. One Food Eosinophilic Esophagitis Diet Study (SOFEED)

The purpose of this interventional study is to test and compare the effectiveness of two elimination diets—the 1-food elimination diet (1FED, milk only) and the 6-food elimination diet (6FED, milk, egg, wheat, soy, tree nut/peanuts, and fish/shellfish). The study will also test the effectiveness of swallowed glucocorticoid therapy in some of the study participants for whom diet therapy was not effective.

Hepatitis

Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection (MINMON)

This study is trying to see whether taking an HCV treatment with fewer clinic visits and laboratory tests can cure just as many people as the standard approach that uses more visits and laboratory tests.

HIV/AIDS

Help End HIV - Red Ribbon Registry

HIV remains a major health issue globally and within the United States. Recent audience research found that many Americans are not aware that HIV is still a health issue in the U.S., are unsure if they might be vulnerable to exposure, and do not know if there is a cure.

Safety and Efficacy Study of Injectable Cabotegravir Compared to Daily Oral Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC), For Pre-Exposure Prophylaxis in HIV-Uninfected Cisgender Men and Transgender Women Who Have Sex With Men

This study will evaluate the safety and efficacy of the injectable drug cabotegravir (CAB LA), for pre-exposure prophylaxis (PrEP) in HIV-uninfected cisgender men and transgender women who have sex with men (MSM and TGW).

Immunologic Diseases

OMEGA Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages (OMEGA)

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms to see if scores on standard questionnaires can give us an idea how well the person is doing.

Lyme Disease (Borreliosis)

Human Immune Response to Ixodes Scapularis Tick Bites

The aim of this study is to learn how peoples’ bodies, particularly the skin, respond to tick bites.