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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

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Arthritis

Rheumatoid Arthritis Studies

NIAID is committed to advancing the understanding of how and why autoimmune diseases such as rheumatoid arthritis occur.

Coronaviruses

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

The primary purpose of NIAID's ACTIV-5/BET study is to evaluate the efficacy of  investigational therapeutics in adults hospitalized for COVID-19.

Flu (Influenza)

Evaluating the Safety and Efficacy of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza

The purpose of this study is to evaluate whether IVIG can reduce the severity and duration of flu in people who are hospitalized with the flu.

Respiratory Virus Hospitalization Study (FLU 003 Plus)

The purpose of this observational study is to describe the characteristics and outcomes over a 60-day follow-up period of participants with influenza virus infection (including influenza A subtypes such as H3N2 and 2009 H1N1, or influenza B), or a targeted non-influenza respiratory virus, who are hospitalized with severe illness and/or complication in geographically diverse locations.

Food Allergy

Six Food vs. One Food Eosinophilic Esophagitis Diet Study (SOFEED)

The purpose of this interventional study is to test and compare the effectiveness of two elimination diets—the 1-food elimination diet (1FED, milk only) and the 6-food elimination diet (6FED, milk, egg, wheat, soy, tree nut/peanuts, and fish/shellfish). The study will also test the effectiveness of swallowed glucocorticoid therapy in some of the study participants for whom diet therapy was not effective.

Hepatitis

Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection (MINMON)

This study is trying to see whether taking an HCV treatment with fewer clinic visits and laboratory tests can cure just as many people as the standard approach that uses more visits and laboratory tests.

Immunologic Diseases

An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)

The purpose of this study is to test the safety and effectiveness of Losartan potassium in subjects with Eosinophilic Esophagitis (EoE), both those with a connective tissue disorder (CTD) and those without a CTD.

OMEGA Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages (OMEGA)

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms to see if scores on standard questionnaires can give us an idea how well the person is doing.

Lupus

Clinical Research Studies of Systemic Lupus Erythematosus

Lupus is an autoimmune disease characterized by inflammation of different tissues of the body. The most common type of lupus is systemic lupus erythematosus (SLE). Women are at far greater risk than men of developing lupus, and SLE disproportionately affects minority populations.