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74 Results

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

Researchers at the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) seek healthy volunteers for a study looking at how common antibiotics affect the trillions of good microbes that live on and in our body, also known as our microbiome.

Allergic Diseases and Eczema (Atopic Dermatitis)

Online Survey About Eczema

This 10- to 20-minute survey is available for patients with eczema or parents of patients with eczema.  These questions will help us learn more about patient experiences to improve current research and guide future research. 

Asthma

Lung-Resident Memory Th2 Cells in Asthma

Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype.

Preventing Asthma in High Risk Kids (PARK)

This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE) for two years will prevent the progression to childhood asthma, as reflected by a reduction in the prevalence of active asthma in the Final 12 months during 2 year observation period off study drug.

Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents (PANDA) (NCT05347771)

Prevention of asthma exacerbations is one of the primary goals of current asthma therapy. New treatment modalities such as biologics are playing an increasing role in asthma management as adjunctive therapy. PANDA is a multi-center, double-blind, placebo-controlled, randomized trial of the biologic dupilumab as adjunctive therapy for prevention of asthma exacerbations in urban children and adolescents with mostly allergic asthma.

Registry for Asthma Characterization and Recruitment 3 (RACR3) (NCT05272241)

There is a need for people to take part in research studies to learn more about diseases and how to treat them. RACR3 will create a database of participants of all ages with asthma and nasal allergies, or risk factors for these conditions, who are potentially eligible for future CAUSE trials.

Autoimmune Diseases and Autoimmune Polyglandular Syndrome Type 1 (APS-1)

A phase 2 open-label study to evaluate the efficacy and safety of ruxolitinib on hair regrowth in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)- associated alopecia areata

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a problem of the immune system. In people with APECED, the immune system makes a mistake and attacks the body. Some people with APECED have a type of hair loss called alopecia areata (AA). No drugs are approved to treat AA or other disease manifestations in APECED. The main aim of this study is to see if a study drug (ruxolitinib) can help hair regrowth in people with APECED-associated AA and if it can improve other symptoms caused by the immune system’s attack to the body.

Autoimmune Diseases

EPIC Study

The primary objective of this NIAID study is to further characterize the natural history of idiopathic CD4 lymphocytopenia (ICL).

Autoimmune Diseases and Immunodeficiency

NIAID Centralized Sequencing Protocol

This study serves as a centralized sequencing protocol for NIH human subjects research studies to facilitate standardization and consolidate accrual of genotype and phenotype data for participating programs.

Chronic Granulomatous Disease (CGD)

Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.

Use of G-CSF to Obtain Blood Cell Precursors

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.

Coronaviruses

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

COVID-19-Acute, Recovered and Vaccination Specimen Collection

The NIAID Vaccine Research Center is looking for volunteers who have been recently infected with or have recovered from COVID-19 infection. We are also looking for those that plan to receive or received a COVID Vaccine to donate blood for research.

Estrategias y tratamientos para infecciones respiratorias y emergencias virales (Strategies and Treatments for Respiratory Infections and Viral Emergencies, STRIVE) Estudio Shionogi S-217622

En este estudio de investigación se evalúa el uso del fármaco antiviral en investigación, S-217622 o ensitrelvir, para tratar adultos hospitalizados con COVID-19 cuando se administra además del tratamiento estándar actual.

Estrategias y tratamientos para infecciones respiratorias y emergencias virales (Strategies and Treatments for Respiratory Infections and Viral Emergencies, STRIVE)

STRIVE es un grupo de estudios de investigación para investigar fármacos y estrategias de tratamiento para adultos hospitalizados con infección respiratoria o pulmonar.

Outpatient Treatment With Anti-Coronavirus Immunoglobulin (OTAC)

A research study testing an experimental COVID-19 treatment called anti-coronavirus hyperimmune intravenous immunoglobulin (hIVIG).

Strategies and Treatments for Respiratory Infections and Viral Emergencies (STRIVE)

STRIVE is a group of research studies to investigate drugs and treatment strategies for adults in the hospital with respiratory or lung infection.

Strategies and Treatments for Respiratory Infections and Viral Emergencies (STRIVE) Shionogi S-217622 Study

This research study tests the use of the investigational antiviral drug, S-217622 or ensitrelvir, to treat adults in the hospital with COVID-19 when given in addition to current standard treatment

Study of How COVID-19 Affects Blood Cells and the Immune System

A study about how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

A study about long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.

Tratamiento ambulatorio con inmunoglobulina anticoronavirus (Outpatient Treatment with Anti-Coronavirus Immunoglobulin, OTAC)

Un estudio de investigación que prueba un tratamiento contra el COVID-19 en fase de investigación conocido como concentrado de inmunoglobulinas de administración intravenosa hiperinmunitarias (hIVIG) anticoronaviral.

Coronaviruses and Flu (Influenza)

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

Are you an NIH staff member? If you have some time and have an interest in helping researchers make discoveries about COVID-19 and influenza, we need you!

We are interested in learning about long-term immunity in people who receive COVID-19 and/or flu vaccines.

Dengue Fever

Dengue Vaccine Research Study

Participate in a compensated research study that will help researchers at the NIH understand how previous dengue infection impacts vaccine responses.

Diabetes

TrialNet Pathway to Prevention of Type 1 Diabetes

The goal of this study is to enhance understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes.

Type 1 Diabetes Extension Study (T1DES)

The goal of this study is to further the understanding of the immunologic mechanisms underlying maintenance and loss of beta cell function by evaluating the relationship between longitudinal changes in beta cell function and changes over time in biomarkers known to be associated with a response to immune modulating treatments used in prior clinical trials.