Flu (Influenza) Studies

You can join the fight against influenza (flu) by volunteering to participate in a clinical study. There is no charge for study-related medical care, including study visits, medications, treatments, and procedures. Volunteers may be compensated for time and travel.

The following are selected studies being conducted at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland. The links lead to full study titles and descriptions.

Evaluating Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza (NCT02287467)
The purpose of this study is to test the safety and effectiveness of an antibody (called intravenous hyperimmune immunoglobulin or IVIG) against the flu in people ages 18 years and older who are hospitalized for severe flu.

High-titer vs. Low-titer Plasma for the Treatment of Severe Influenza A (NCT02572817)
This randomized, double-blinded, multicenter phase 3 trial assesses the efficacy and safety of high-titer versus low-titer anti-influenza immune plasma in addition to standard of care antivirals for the treatment of severe influenza A. Hospitalized people with severe influenza A are eligible for study participation. Adults and children may participate, and there is no exclusion for pregnancy.

Influenza in People With Normal or Weakened Immune Systems (NCT00533182)
This study is enrolling people 3 years of age and older who were clinically diagnosed with the flu within the past two months and are able to safely undergo blood draws and nasal washes. The purpose of this study is to evaluate how the immune system responds to influenza infection and compare how the infection differs in patients with a weakened immune system versus those with a healthy immune system.

Viral Infections in Non-immunocompromised Patients (NCT01011712)
This study is enrolling people of any age who are thought to have normal immune systems but who have been diagnosed with a viral infection that is unusually severe, prolonged, or persistent. This study will evaluate the participants’ immune systems to determine why the infection developed.

Screening Volunteers for Influenza Challenge Studies (NCT01386424)
This study is screening healthy volunteers ages 18 to 50 for potential participation in future influenza challenge studies that will help researchers find better ways to prevent and treat the flu.

Don't live in the Washington, DC, area? See NIAID-supported influenza clinical research studies being conducted across the United States and around the world.

Read more about NIAID influenza research.

Content last reviewed on February 10, 2017