People with hyper-immunoglobulin E syndrome (HIES), aka Job’s Syndrome, have recurrent infections of the skin and lungs caused by bacteria. NIAID-supported research seeks to determine the effect of Job’s Syndrome on the immune system, including which immune cells and responses are affected and how these abnormalities translate into patients’ symptoms.
Current Clinical Research Studies Seeking Volunteers
The following are selected clinical trials supported by NIAID and investigating various aspects related to Job’s Syndrome. The links lead to full study descriptions, eligibility criteria and contact information.
00-I-0159: Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection
This study is enrolling patients and families with a confirmed or suspected diagnosis of HIES for extensive phenotypic and genotypic study as well as disease management. Findings from this study may help identify further genetic etiologies and gain a better understanding of the pathogenesis of HIES.
07-I-0033: Detection and Characterization of Infections and Infections Susceptibility
This screening study examines the causes of immune disorders affecting white blood cells, which defend against infections, and try to develop a means of diagnosis and treatment of these immune disorders. People with known or suspected increased susceptibility to infections and their blood relative may be eligible for this study.
16-I-0002: CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis (CAMB)
This study seeks to determine the efficacy, safety, and pharmacokinetics of a novel oral formulation of the antifungal amphotericin. People ages 18 to 75 years with chronic mucocutaneous candidiasis who are not responding to standard non-intravenous treatment may be eligible to participate.
Read about NIAID research on hyper-immunoglobulin E syndrome or Job’s Syndrome.