Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

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Join the microbiome healthy volunteer clinical trial if you are age 18-49, have no chronic medical problems, and have no known allergies to Amoxicillin or Azithromycin

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Researchers at the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) seek healthy volunteers for a study looking at how common antibiotics affect the trillions of good microbes that live on and in our body, also known as our microbiome.

What Does the Study Involve?

During this study, participants may:

  • Be asked to take the antibiotic Amoxicillin or Azithromycin or act as a control (no antibiotic)
  • Have up to 11 outpatient visits over a one-year time period
  • Choose to be part of a sub study that includes three overnight stays in an environmentally controlled room that measures the body’s energy use at the NIH Clinical Center

Who Can Participate?

 You may be eligible if you:

  • Are 18-49 years old
  • Have no chronic medical problems
  • Have no known allergies to Amoxicillin or Azithromycin
  • Are willing to allow storage of their biological samples
  • Are able to comply with study procedures and swallow capsules

Where Is It Taking Place?

The NIH Clinical Center, America’s Research Hospital, located in Bethesda, MD.

Is There a Cost?


Is Compensation Provided?

Yes. If participants complete all 11 outpatient study visits, they may be compensated up to $1,270. If participants elect to participate in the optional metabolic chamber portion of the study, total compensation is $2,860. These values do not include the amounts paid for unscheduled visits.

How Many Visits Are Required?


What Are the Steps To Participate?

Potential participants can reach out to the study coordinator, Jessica Grenard, PA-C at Jessica.grenard@nih.gov or by phone at 240-627-3408. They can also contact the Office of Patient Recruitment at 866-444-8810 or ccopr@nih.gov.


Visit ClinicalTrials.gov for details.

Contact Information

Phone: 240-627-3408

Email: Jessica.grenard@nih.gov

Hours:  Monday-Friday 8:00am-5:00pm

Participating in Research

Watch a series of short informational videos about participating in clinical trials. These videos are intended to help potential participants understand how research works, what questions they should consider asking, and things to think about when deciding whether or not to participate in a study.

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