Concepts represent early planning stages for program announcements, requests for applications, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.
NB: Council approval does not guarantee that a concept will become an initiative.
Table of Contents
- Immune Response to Arthropod Blood Feeding
- Nonhuman Primate (NHP) Radiation Survivor Cohort
- Centers for Medical Countermeasures Against Radiation Consortium
- Radiation Biodosimetry Assays and Devices
- NIH Tetramer Core Facility
- Atopic Dermatitis Research Network
For the published program announcement with special receipt, referral, and/or review considerations, see the July 19, 2018 Guide announcement, Immune Response to Arthropod Blood Feeding (R21, Clinical Trial Not Allowed).
Request for Applications—proposed FY 2020 initiative
Contact: Andrea DiCarlo-Cohen
Objective: This initiative will allow for preserving an extremely valuable, large animal resource. The ability to adopt, monitor, and treat NHP survivors of radiation exposure provides information that is critical to understanding the natural history of radiation exposures, to include early and late injuries and disease development. NHPs are widely considered to be the animal model that most closely resembles human responses to radiation exposure, and as such, the survivor colony will permit continuous observations and treatment of these important animals.
Description: This new initiative will support the following, including but not limited to: maintaining an occupational health program as well as research and training for employees working with NHPs; environmental enrichment and behavioral monitoring of NHPs; pathology and necropsy (to include histology and immunohistochemistry); sample imaging; irradiation facilities; funding for clinical studies and other laboratory space (to enable standard analyses such as serum chemistries, blood counts, as well as molecular and cellular analyses); funds to provide animal transport to and from the site for adoptions and evaluations; providing per diem expenses to house, feed, evaluate, and treat NHP radiation survivors and age-matched, unirradiated control animals; funding to carry out radiographic exams (e.g., x-rays, CTs, MRIs) to evaluate animal health status; and funding to maintain a catalogue/database of available samples and data to be made available to the research community for a nominal fee through a reviewed process.
For the published request for applications, see the February 8, 2019 Guide announcement, Centers for Medical Countermeasures Against Radiation Consortium (U19 Clinical Trial Not Allowed).
For the published request for applications, see the October 10, 2018 Guide announcement, Radiation Biodosimetry Assays and Devices (U01 Clinical Trial Not Allowed).
For the published request for proposals, see the September 26, 2018 solicitation, NIH Tetramer Core Facility.
Request for Applications—proposed FY 2020 initiative
Contact: Kelly Stone
Objective: This initiative aims to further improve our understanding of the defense mechanisms of the skin and host defense defects leading to infection susceptibility by focusing on differences in skin structure/function and in immune responses among patients with atopic dermatitis, healthy individuals, or disease controls. Furthermore, this initiative will implement interventions aimed at improving the skin’s immune and barrier function in order to improve cutaneous defenses and, consequently, prevent infectious complications and the acute and long-term impact of atopic dermatitis on the health of children and adults.
More specifically, research areas to be pursued by the proposed Atopic Dermatitis Research Network (ADRN) initiative include:
- Evaluating the immune and skin barrier impairments leading to cutaneous viral (e.g., herpes simplex) and bacterial (e.g., S. aureus) infections
- Evaluating the role of the skin microbiome in host defense, including the effects of microbiome perturbations on cutaneous immunity, and the effects of targeted biologic treatments on the skin microbiome
- Evaluating the role of proteins in both the stratum corneum and the tight junctions, as well as the role of cutaneous lipids in host defense and in the chronic inflammatory aspects of atopic dermatitis
- Studying the genetic and epigenetic basis of the cutaneous host defense abnormalities and the chronic inflammatory aspects of atopic dermatitis in children and adults, including susceptibility to eczema herpeticum and eczema vaccinatum
- Designing and conducting clinical trials to treat atopic dermatitis and its chronic consequences on skin function and defenses in children and adults, as well as on the long-term inflammatory consequences in children
- Developing and validating sample-sparing assays and non-invasive methods to study cutaneous immunity and characterizing the cutaneous microbiome in infancy
The above research focus includes some modifications in scope in order to follow up on the most promising research results obtained by the current ADRN. These include 1) emphasis on the role of microbiome in developing and maintaining atopic dermatitis and immune function, 2) further dissection of the mechanisms of microbiome-cutaneous immune system interactions, through microbiome and cutaneous immunity perturbations, 3) inclusion of broader agnostic, systems biology approaches, including genomics, transcriptomics, proteomics, and lipidomics, and 4) studying immune responses to atopic dermatitis-associated pathogens in other skin conditions, such as ichthyosis or psoriasis, as controls.
Description: This initiative will support a network of investigators with expertise in dermatology, allergy and immunology, infectious diseases, and the genetics of atopic dermatitis. Awardees will conduct collaborative and single-site studies, including clinical trials and observational studies, in humans and animal models.