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June 2021 DAIDS Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

NB: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Fiscal Year (FY) 2022 Concepts

FY 2022 Small Business Innovation Research (SBIR) Contract Solicitation Topic

FY 2023 Concepts

Brazil Regional Prospective Observational Research in Tuberculosis (RePORT)

For the published program announcement with special receipt, referral, or review considerations, see the August 5, 2021 Guide announcement, Brazil Regional Prospective Observational Research in Tuberculosis (RePORT) (U01, Clinical Trial Not Allowed). 

Notice of Special Interest (NOSI)—HIV Drug Resistance Assays and Actionable Data Dissemination Strategies

For the published notice of special interest, check the June 17, 2021 Guide notice, Notice of Special Interest (NOSI)—HIV Drug Resistance Assays and Actionable Data Dissemination Strategies.

Notice of Special Interest (NOSI)—HIV/AIDS in the Era of COVID-19 - When Pandemics Collide

For the published notice of special interest, check the June 25, 2021 Guide notice, Notice of Special Interest (NOSI)—HIV/AIDS in the Era of COVID-19 - When Pandemics Collide.

Development of Diagnostics To Differentiate HIV Infection From Vaccine-Induced Seropositivity

For the published request for proposals, check the July 30, 2021 solicitation, A Solicitation of the National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC) for Small Business Innovation Research (SBIR) Contract Proposals.

Development of Assays for Testing Susceptibility to Broadly Neutralizing Antibodies (bNAbs)

For the published request for applications, check the March 10, 2022 Guide announcement, Development of HIV Broadly Neutralizing Antibody Susceptibility Assays (R61/R33, Clinical Trial Not Allowed).

South Africa Regional Prospective Observational Research in Tuberculosis (RePORT)

Request for Applications—proposed FY 2023 initiative

Contact: Sudha Srinivasan

Objective: The primary objective of this initiative is to enable a network of South African and U.S. scientists to advance current understanding of the community, host, and microbial factors that impact outcomes of tuberculosis (TB) infection and TB disease, especially among persons with HIV (PWH), including drug-resistant TB, to facilitate development of tools to improve treatment outcomes at the individual level and to inform strategies to curtail the TB epidemic at the public health level.

To achieve this, the initiative will support a South Africa-U.S. Regional Prospective Observational Research in Tuberculosis (RePORT) network that will leverage the robust clinical research infrastructure that exists within South Africa to capacitate this research.

Description: To advance high-priority research for the United States and the South Africa Medical Research Council (SAMRC), applicants will leverage clinical samples and data from existing prospective longitudinal cohorts that include participants with active TB disease and their contacts.

Research projects supported through this initiative may include, but are not limited to, the areas below. The priorities will be further delineated in collaboration with the SAMRC.

  • Studies to identify/validate biomarkers and biosignatures for TB progression risk/prevention, diagnosis, prognosis, and treatment monitoring
  • Discovery/confirmation of host and microbial factors that affect the development risk, dynamics, pathophysiology, outcomes, and transmission of active TB and TB/HIV in children and adults
  • Studies to support new and continued development of TB vaccines
  • Observation and implementation studies that bridge the knowledge-practice gap in TB and TB/HIV diagnosis, treatment, and prevention

This initiative will not support the following:

  • Collection of only epidemiological data
  • Establishment of de novo clinical cohorts
  • Clinical trials

If additional clinical specimens and data are needed to answer the research proposed, the applicant may propose to collect additional samples and data. In this case, the applicant is required to leverage existing infrastructure, and must have the capacity to implement the observational research as per the RePORT International standards. It is expected that the successful applicant for the RePORT South Africa Network will participate in the international effort to advance TB research with a focus on research to improve the health of PWH including participation in the RePORT International Consortium. 

Applicants must develop a method to establish and/or maintain a collaboration with the Southern Africa International epidemiology Databases to Evaluate AIDS (IeDEA) network in order to facilitate standardized collection and sharing of TB/HIV epidemiological and clinical data.

RePORT International Coordinating Center (RICC)

For the published request for applications, see the November 2, 2021 Guide announcement, RePORT International Coordinating Center (RICC) (U01, Clinical Trial Not Allowed).

Biomarker Signatures of Tuberculosis Infection in Young Children With and Without HIV

For the published request for applications, check the February 10, 2022 Guide announcement, Biomarker Signatures of TB Infection in Young Children With and Without HIV (R01 Clinical Trial Not Allowed)

Resources To Advance Pediatrics and HIV Prevention Science (RAPPS)

For the published request for proposals, check the March 7, 2022 solicitation, Resources To Advance Pediatrics and HIV Prevention Science. 

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