May 2015 DAIDS Council-Approved Concepts

Concepts represent early planning stages for program announcements, request for applications, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to the Opportunities and Announcements portal.

Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Understanding HIV Persistence in Infants—FY 2016

For the published program announcement, see the June 5, 2015 Guide announcement, Understanding HIV Persistence in Infants (R01).

Understanding HIV Persistence in Infants—FY 2017

Request for Applications—Proposed FY 2017 initiative

Contact: Devasena Gnanashanmugam

Objective: This initiative is intended to advance the existing knowledge of the pathogenesis of perinatal HIV-1 infection by exploring the unique aspects of the infant's developing immune system and its interaction with the virus, including establishing HIV-specific immune responses as well as viral reservoirs in order to elucidate novel strategies for HIV-1 remission.

Description: This initiative will solicit applications that examine unique aspects of the pathogenesis of perinatal HIV infection and the infant immune response as they relate to establishment of HIV reservoirs. It will support the following:

  • Exploring the developing immune system, such as infant immune tolerance and age-dependent maturation of innate and adaptive immune responses to HIV infection
  • Developing broadly neutralizing antibodies to HIV in early life
  • Mucosal immune responses

It will also support research related to viral reservoir dynamics in the perinatally-infected infant:

  • Contribution of latency and low-level ongoing replication to HIV persistence
  • Comparative characterization of latent reservoir dynamics
  • Association of duration of viral suppression in relation to time of infection, rate of viral decay, immune status, and other factors

This initiative will not support clinical trials.

Understanding HIV Rebound

For the published request for applications, see the April 19, 2016 Guide announcement, Understanding HIV Rebound (P01).

External Quality Assurance Program Oversight Laboratory (EQAPOL)

For the published request for proposals, see the April 5, 2016 solicitation, External Quality Assurance Program Oversight Laboratory.

Identification of Small Molecules for Sustained-Release Anti-HIV Products

For the published request for applications, see the April 6, 2016 Guide announcement, Identification of Small Molecules for Sustained-Release Anti-HIV Products (R01).

Pilot Clinical Trials to Eliminate the Latent HIV Reservoir

For the published request for applications, see the March 10, 2016 Guide announcement, Pilot Clinical Trials to Eliminate the Latent HIV Reservoir (U01).

Mycobacterium tuberculosis (Mtb) Quality Assessment (TBQA) Program

For the published request for proposals, see the December 8, 2015 solicitation, Mycobacterium tuberculosis (Mtb) Quality Assessment (TBQA) Program.

Pediatric Biomarker Discovery for Improved Diagnosis of TB Disease

For the published request for applications, see the November 24, 2015 Guide announcement, Pediatric Diagnostic Biomarkers for Active Pulmonary TB Disease (R01).

DAIDS Regulatory Support Center (RSC)

For the published request for proposals, see the February 4, 2016 solicitation, NIAID/Division of AIDS: Regulatory Support Center.

DAIDS Clinical Research Support Services (CRSS)

For the published request for proposals, see the April 29, 2016 solicitation, NIAID HIV and Other Infectious Diseases Clinical Research Support Services (CRSS).

NIAID Clinical Site Monitoring

For the published request for proposals, see the January 15, 2016 solicitation, NIAID Clinical Site Monitoring.

Ethical Issues in Research With Key Populations

For the published program announcements with special receipt, referral, and/or review considerations, see the August 10, 2015Guide announcements, Ethical, Legal, and Policy Issues in HIV Research With Key Populations (R01) and Ethical, Legal, and Policy Issues in HIV Research With Key Populations (R21).

Exploiting RNA as a Target for HIV Interventions

For the published program announcement, see the June 5, 2015 Guide announcement, Exploiting RNA as a Target for HIV Interventions (R21).

Harnessing Big Data to Halt HIV

For the published program announcement, see the June 5, 2015 Guide announcement, Harnessing Big Data to Halt HIV (R01).

Content last reviewed on April 26, 2016