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December 2020

Peer-Reviewed Report on Moderna COVID-19 Vaccine Publishes

December 30, 2020

The investigational vaccine known as mRNA-1273 was 94.1% efficacious in preventing symptomatic coronavirus disease 2019 (COVID-19), according to preliminary results from a Phase 3 clinical trial reported in the New England Journal of Medicine. The vaccine also demonstrated efficacy in preventing severe COVID-19. Investigators identified no safety concerns and no evidence of vaccine-associated enhanced respiratory disease (VAERD). 

Dr. Fauci is sitting while a healthcare worker administers a vaccine in his upper arm.

Phase 3 Trial of Novavax Investigational COVID-19 Vaccine Opens

December 28, 2020

A NIH-supported Phase 3 trial of another investigational coronavirus disease 2019 (COVID-19) vaccine has begun enrolling adult volunteers.

Results of NIH-Sponsored ACTIV-3 Trial Published

December 22, 2020

Preliminary results of a NIH Phase 3 clinical trial testing an investigative monoclonal antibody in hospitalized COVID-19 patients were published.

Cell infected with SARS-CoV-2 virus

Reston Ebolavirus Spreads Efficiently in Pigs

December 21, 2020

Reston ebolavirus should be considered a livestock pathogen with potential to affect other mammals, including people, according to NIH scientists.

This colorized transmission electron micrograph shows a slice of Reston virus particles (blue) in the lung of an infected pig.

Statement from NIH and BARDA on the FDA Emergency Use Authorization of the Moderna COVID-19 Vaccine

December 18, 2020

The FDA issued an Emergency Use Authorization to Moderna, Inc. for its COVID-19 vaccine, which was co-developed with scientists at NIH NIAID and Moderna.

Investigational COVID-19 Therapeutics to be Evaluated in Large Clinical Trials

December 17, 2020

Two NIH-sponsored Phase 3 clinical trials are evaluating investigational monoclonal antibodies for treating people hospitalized with COVID-19.

A scanning electron micrograph shows an apopototic cell heavily infected with SARS-CoV-2 virus particles

NIH Observational Study of Coronavirus Infection and Multisystem Inflammatory Syndrome in Children Begins

December 16, 2020

A NIH study launched to evaluate the health outcomes of SARS-CoV-2 infection in children and to characterize the disease presentations and outcomes.

Cell infected with the SARS-CoV-2 virus

Baricitinib Plus Remdesivir Shows Promise for Treating COVID-19

December 11, 2020

A NIAID supported study indicated possible ways to reduce time to recovery for people hospitalized with COVID-19.

A transmission electron micrograph showing particles of the SARS-CoV-2 virus

NIH Statement on World AIDS Day 2020

December 01, 2020

Today on World AIDS Day, we reflect both on the remarkable progress that has been made against HIV as well as the considerable challenges that remain. We now have highly effective HIV treatment and prevention methods, and work is underway to address the remaining challenges in delivering these tools to the people who need them most, as well as to develop new interventions. The National Institutes of Health continues to advance rigorous, innovative research to prevent new HIV transmissions and improve the health of people with HIV worldwide. 

November 2020

NIH Announces Restructured HIV Clinical Trials Networks

November 30, 2020

NIAID announced the clinical investigators and institutions that will lead four NIH HIV clinical trials networks over the next seven years.

Experimental Vaccine for Deadly Tickborne Virus Effective in Cynomolgus Macaques

November 30, 2020

An experimental vaccine to prevent infection by Crimean-Congo hemorrhagic fever virus has protected cynomolgus macaques in a new NIH study.

Geographic distribution of Crimean-Congo Haemorrhagic Fever

Statement—Fourth Iteration of COVID-19 Treatment Trial Underway

November 25, 2020

NIAID announced that the Adaptive COVID-19 Treatment Trial has begun to enroll hospitalized adults with COVID-19 who require supplemental oxygen.

red circular virus particles with orange surface spikes

Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine

November 16, 2020

An independent review of NIH data suggests that the mRNA-1273 vaccine is safe and effective at preventing symptomatic COVID-19 in adults.

Treatments for People with Early COVID-19 Infection is an Urgent Research Focus

November 11, 2020

COVID-19 treatments for people with early infection are needed urgently, according to a JAMA Viewpoint article by NIAID Director Anthony S. Fauci, M.D., and colleagues. Treating people early in the course of infection with SARS-CoV-2, the virus that causes COVID-19, would speed their recovery, reduce the likelihood that they develop severe outcomes and reduce demand on the healthcare system, they write.

Colorized scanning electron micrograph of a cell heavily infected with SARS-CoV-2 virus particles (yellow), isolated from a patient sample.

Statement—NIH Study Finds Long-Acting Injectable Drug Prevents HIV Acquisition in Cisgender Women

November 09, 2020

A pre-exposure prophylaxis (PrEP) regimen containing an investigational long-acting form of the HIV drug cabotegravir injected once every eight weeks was safe and more effective than a daily oral PrEP regimen at preventing HIV acquisition among a group of cisgender women. The women, from southern and east Africa, are enrolled in a clinical trial sponsored by the National Institutes of Health.

October 2020

Statement—NIH-Sponsored ACTIV-3 Trial Closes LY-CoV555 Sub-Study

October 26, 2020

The ACTIV-3 clinical trial evaluating the investigational monoclonal antibody LY-CoV555 in hospitalized patients with COVID-19 will not enroll more participants into this sub-study following a recommendation from the independent Data and Safety Monitoring Board (DSMB). The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. 

Landmark TB Trial Identifies Shorter-Course Treatment Regimen

October 21, 2020

Results from a CDC and NIAID-sponsored clinical trial identify shorter-course treatment regimen for tuberculosis (TB).

NIH Study Aims To Identify Promising COVID-19 Treatments for Larger Clinical Trials

October 13, 2020

NIAID launches a new study to identify promising COVID-19 treatments for larger clinical trials.

Scanning electron microscope image shows SARS-CoV-2 (round gold objects) emerging from the surface of cells cultured in the lab.

NIH Clinical Trial Testing Hyperimmune Intravenous Immunoglobulin Plus Remdesivir to Treat COVID-19 Begins

October 08, 2020

An NIH clinical trial began to test the hyperimmune intravenous immunoglobin plus remdesivir combination treatment regimen for COVID-19.

Transmission electron micrograph of SARS-CoV-2 virus particles

September 2020

BULLETIN—NIAID Stops Enrollment of Severely Ill COVID-19 Participants in Clinical Trial of Investigational Treatments

September 29, 2020

The Adaptive COVID-19 Treatment Trial 3 (ACTT-3), sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, will no longer enroll hospitalized participants with severe COVID-19 requiring high-flow oxygen, and will not begin to enroll patients requiring non-invasive or invasive mechanical ventilation.

Investigational COVID-19 Vaccine Well-Tolerated and Generates Immune Response in Older Adults

September 29, 2020

An investigational mRNA vaccine to prevent SARS-CoV-2 infection generates a strong immune response in a NIAID-supported Phase 1 trial.

A transmission electron micrograph showing SARS-CoV-2 virus particles

Scientists Discover Genetic and Immunologic Underpinnings of Some Cases of Severe COVID-19

September 24, 2020

New findings by scientists at the National Institutes of Health and their collaborators help explain why some people with COVID-19 develop severe disease. The findings also may provide the first molecular explanation for why more men than women die from COVID-19. 

Scanning electron micrograph of a cell infected with SARS-CoV-2

Fourth Large-Scale COVID-19 Vaccine Trial Begins in the United States

September 23, 2020

A fourth Phase 3 NIH clinical trial evaluating an investigational vaccine for coronavirus disease 2019 (COVID-19) has begun enrolling adult volunteers.

Gloved hand holding a vial of Johnson and Johnson COVID-19 vaccine candidate

Probiotic Skin Therapy Improves Eczema in Children, NIH Study Suggests

September 09, 2020

An experimental treatment for eczema safely reduced disease severity and increased quality of life for children as young as 3 years old, NIH study shows.

Left panel shows inner elbow covered with red rash and right panel shows inner elbow with clear skin

August 2020

Phase 3 Clinical Testing in the U.S. of AstraZeneca COVID-19 Vaccine Candidate Begins

August 31, 2020

A NIAID-supported Phase 3 clinical trial evaluating an investigational COVID-19 vaccine called AZD1222 will enroll around 30,000 adult volunteers.