NIH-funded scientists have shown that boosting the production of certain broadly neutralizing antibodies can protect humanized mice from both intravenous and vaginal infection with HIV. Humanized mice have immune systems genetically modified to resemble those of humans, making it possible for them to become HIV-infected.
Balazs AB et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nature Medicine DOI: 10.1038/nm.3471 (2014).
NIAID director Anthony S. Fauci, M.D., is available to discuss the findings.
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