Scientists are pursuing injections or intravenous infusions of broadly neutralizing HIV antibodies (bNAbs) as a strategy for preventing HIV infection. This technique, called passive immunization, has been shown to protect monkeys from a monkey form of HIV called simian human immunodeficiency virus, or SHIV. To make passive immunization a widely feasible HIV prevention option for people, scientists want to modify bNAbs such that a modest amount of them is needed only once every few months.
S-Y Ko, et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature DOI: 10.1038/nature13612 (2014).
NIAID Director Anthony S. Fauci, M.D. and NIAID Vaccine Research Director John R. Mascola, M.D., are available for interviews.
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