An extensive database identifying immune traits, such as how immune cell function is regulated at the genetic level in healthy people, is reported by researchers from the National Institutes of Health (NIH) and their collaborators in the journal Cell. While many genetic risk factors have been linked to various diseases, including autoimmune disorders, how a genetic change causes susceptibility to a disease is not always clear. By studying healthy people, researchers from the National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center, part of the NIH, and colleagues from King's College London have created a reference resource for other scientists.
M Roederer, L Quaye, M Mangino et al. The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis. Cell DOI: 10.1016/j.cell.2015.02.046 (2015).
Mario Roederer, Ph.D., chief of the ImmunoTechnology Section in NIAID's Vaccine Research Center, is available to discuss the findings.