By analyzing the blood of almost 100 treated and untreated HIV-infected volunteers, a team of scientists has identified previously unknown characteristics of B cells in the context of HIV infection. B cells are the immune system cells that make antibodies to HIV and other pathogens. The findings augment the current understanding of how HIV disease develops and have implications for the timing of treatment. Researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, led the study.
L Kardava et al. Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. The Journal of Clinical Investigation DOI: 10.1172/JCI74351 (2014).
Anthony S. Fauci, M.D., NIAID director and chief of the NIAID Laboratory of Immunoregulation (LIR); and Susan Moir, Ph.D., LIR associate scientist, are available for comment.
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