The IRP COVID-19 Dashboard mentioned above also contains a list of reagents available to NIH researchers. NIH researchers without direct access to the dashboard may find relevant information in our spreadsheet of IRP COVID-19 reagents (Excel Spreadsheet), also NIH-only. Distribution of any of the reagents is at the discretion of the principal investigator. If you have COVID-related reagents you are willing to make available to other IRP PIs, please fill out the form for the NIH COVID-19 Reagent Registry (for NIH staff; does not require VPN).
Other Datasets, Repositories, and Scientific Resources
The following list provides links to resources to assist in your research on SARS-CoV-2 and COVID-19. Please remember any work with potentially pathogen material including COVID-19 patient samples requires registration with the NIH IBC prior to any work being performed. These materials are registered as human blood and body fluids (COVID-19 Patient). Materials and recombinant experiments, if applicable, are registered through the PI Dashboard (oms.ors.nih.gov). Contact your IC assigned safety representative for additional help or the NIH Biological Safety Officer, Rick Baumann, at firstname.lastname@example.org.
- Addgene: Addgene is a global, nonprofit repository that was created to help scientists share plasmids. Addgene has several COVID-19 and coronavirus plasmids and resources available.
- Animal Models for COVID-19: The animal model summaries and descriptions have been curated by the National Institutes of Health (NIH) Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Preclinical Working Group with support from the Foundation for the National Institutes of Health (FNIH). New and updated information, including detailed individual animal model pages, will be provided as more scientific studies are shared.
- AWS COVID-19 Genome Sequence Dataset: A centralized sequence repository for all strains of novel corona virus (SARS-CoV-2) submitted to the National Center for Biotechnology Information (NCBI). Included are both the original sequences submitted by the principal investigator as well as SRA-processed sequences that require the SRA Toolkit for analysis.
- BEI Resources Repository: BEI Resources was established by the National Institute of Allergy and Infectious Diseases (NIAID) to provide reagents, tools and information for studying Category A, B, and C priority pathogens, emerging infectious disease agents, non-pathogenic microbes and other microbiological materials of relevance to the research community. BEI Resources is prioritizing and fast-tracking all SARS-CoV-2 registrations. For SARS-CoV-2 requests, BEI anticipates a 24–72-hour registration turn-around time.
- COVID-19 Digital Pathology Repository: The COVID Digital Pathology Repository (COVID-DPR) is a resource to support the biomedical community as we confront the pandemic of the COVID-19 virus. The goal of the COVID-DPR is to make whole slide images (WSI) of COVID related pathology available as a resource to the community.
- COVID-19 Treatment Guidelines: These treatment guidelines have been developed to inform clinicians how to care for patients with COVID-19. Because clinical information about the optimal management of COVID-19 is evolving quickly, these guidelines are updated frequently as published data and other authoritative information becomes available.
- COVID-19 Open Research Dataset Challenge (CORD-19): In response to the COVID-19 pandemic, the NIH, Allen Institute, and other leading research groups have prepared this resource of more than 128,000 scholarly articles, including over 59,000 with full text, about COVID-19, SARS-CoV-2, and related coronaviruses.
- CREx: CREx is the collaborative research exchange for the NIH IRP. It enables PIs to find innovative services and suppliers and place orders for services or products they require. CREx has pre-established supplier legal and finance agreements that cover confidentiality, IP protection, and purchasing terms to allow for purchase on demand.
- Jax Labs: The K18ACE2 tg mice expressing human ACE2 as a multicopy transgene are becoming available from Jax Labs. Humanized ACE2 mouse strains in which the endogenous ACE2 gene is mutated at a single or at multiple residues to enable virus entry into cells are being generated. Investigators at NIAID's Rocky Mountain Labs will be comparing the K18ACE2 and humanized ACE2 mice directly in terms of SARS-CoV-2 infection with the intent of making mice available to NIH researchers. Further information will be shared as available and when animals are closer to being ready for distribution by Jax.
- iSearch COVID-19 portfolio: The iSearch COVID-19 portfolio is NIH’s comprehensive, expert-curated source for publications related to COVID-19. This COVID-19 Portfolio tool leverages the cutting-edge analytical capability of the iSearch platform, with its powerful search functionality and faceting, and includes articles from PubMed and pre-prints from medRxiv, SSRN, arXiv, bioRxiv, Research Square and ChemRxiv. The portfolio is updated daily with the latest available data.
- NCBI SARS-CoV-2 Resources: Comprehensive access to the NLM's literature, sequence, and clinical studies information
- NCI DCEG Biorepository: The NCI’s Division of Cancer Epidemiology and Genetics (DCEG) has established a repository for human-derived samples related to COVID-19 studies in the IRP within the existing DCEG biorepository, which already houses over 11 million tracked samples. You are invited to store such sample in this DCEG repository. They will be catalogued and tracked to assure proper storage and stewardship. The samples will be distributed according to the direction of the study’s PI. Please note that broad sharing through collaborations between IRP investigators and the extramural community (via appropriate MTAs) is expected in order to facilitate the rapid dissemination of science for the public good. Investigators with IRB-approved COVID projects that would like human biospecimen samples to be banked in the repository should contact Dr. Mandy Black in DCEG at email@example.com. Unfortunately, live virus isolates and single samples cannot be stored at this time, but arrangements can be made to store samples that might be contaminated with virus. If extensive aliquoting is necessary when samples are requisitioned, there may be a fee for service depending on the amount of work involved. Otherwise, DCEG has agreed to cover the costs of this important service. A catalogue of the contents of the repository will be made available very soon.
- NIAID’s COVID Resources for Researchers: Resources to support research and product development at each stage of the pipeline.
- OpenData COVID-19: NCATS is generating a collection of datasets by screening a panel of SARS-CoV-2-related assays against all approved drugs. These datasets, as well as the assay protocols used to generate them, are being made immediately available to the scientific community on this site as these screens are completed
- ViPR for structural and genomics data: The Influenza Research Database (IRD) and Virus Pathogen Resource (ViPR) are freely available, NIAID-funded resources that support the research of viral pathogens in the NIAID Category A-C Priority Pathogen lists and those causing re-emerging infectious diseases. IRD and ViPR integrate data from external sources (GenBank, UniProt, Immune Epitope Database, Protein Data Bank, etc.), direct submissions, and internal curation and analysis pipelines, and provide a suite of bioinformatics analysis and visualization tools to expedite virology research.