Center for the Study of Complex Malaria in India
Principal Investigator: Jane Carlton, Ph.D.
Lead Institution: Center for Genomics and Systems Biology, Department of Biology, New York University, New York
- Surya Kant Sharma, National Institute of Malaria Research
- Jane Carlton, New York University
- Samuel Wassmer, London School of Hygiene and Tropical Medicine
- National Institute of Malaria Research: Headquarters, New Delhi, India; Chennai Field Site, Tamil Nadu, India; Raukela Field Site, Odisha, India; Niadiad Field Site, Gujarat, India
- Ispat General Hospital, Raurkela, India
- Pennsylvania State University, State College
The India ICEMR will explore the analysis of mixed-species and mixed-genotype infections generated by the two predominant human malaria species in India, Plasmodium falciparum and P. vivax. The research team will also study how such infections influence disease outcome, vector transmission, and drug resistance.
Malaria is a significant public health burden in India. The India ICEMR will use cutting-edge genomics technology in an attempt to find better ways to diagnose and treat patients with resistant malaria parasites.
View Associated sites in India (Rourkela, Orissa; Chennai, Tamil Nadu; Nadiad, Gujarat) in a larger map.
- van Eijk AM et al. The use of mosquito repellents at three sites in India with declining malaria transmission: surveys in the community and clinic. Parasit Vectors. 2016 Jul 27;9(1):418. doi: 10.1186/s13071-016-1709-9.
- Rao PN et al. A Method for Amplicon Deep Sequencing of Drug Resistance Genes in Plasmodium falciparum Clinical Isolates from India. J Clin Microbiol. 2016 Jun;54(6):1500-11. doi: 10.1128/JCM.00235-16.
- van Eijk AM et al. What is the value of reactive case detection in malaria control? A case-study in India and a systematic review. Malar J. 2016 Feb 6;15:67. doi: 10.1186/s12936-016-1120-1.
- Hupalo DN, Bradic M, Carlton JM. The impact of genomics on population genetics of parasitic diseases. Current Opinion in Microbiology. Volume 23, February 2015, Pages 49–54.
- Mideo N et al. Ahead of the curve: next generation estimators of drug resistance in malaria infections. Trends in Parasitology, 29: 321-328. http://mideo.eeb.utoronto.ca/files/2013/10/Mideo_AOTC.pdf
- Cator LJ et al. Do malaria parasites manipulate mosquitoes? Trends in Parasitology; Volume 28, Issue 11, p466–470, November 2012.
- Carlton JM, Das A, Escalante AA. Genomics, population genetics and evolutionary history of Plasmodium vivax. Advances in Parasitology; 01/2013; 81:203-22. DOI: 10.1016/B978-0-12-407826-0.00005-9.
- Bell AS et al. Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria. PloS One. June 2012. DOI: 10.1371/journal.pone.0037172.
- Mohanty S et al. Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis? Malaria Journal. 2014, 13:276; DOI: 10.1186/1475-2875-13-276.
- Gene Sequences Reveal Global Variations in Malaria Parasites
- Understanding How Temperature Can Impact the Intensity of Malaria Transmission
- Environmental Temperature Is an Important Driver of Malaria Transmission Dynamics
- First Plasmodium vivax and Plasmodium falciparum Whole Genome Assemblies From India
- All Featured Research From the ICEMR Program