Center for the Study of Complex Malaria in India
Principal Investigator: Jane Carlton, Ph.D.
Lead Institution: New York University, New York
Award date: 2010; renewed in 2017
- Sam Wassmer, London School of Hygiene and Tropical Medicine, London, UK
- Kishore Mahanta, Ispat General Hospital, Rourkela, India
- Joe Smith, Center for Infectious Disease Research, Seattle, USA
- Sandra Albert, Indian Institute of Public Health, Shilong, India
- Aparup Das, Centre for Research in Medical Entomology, Madurai, India
- Daniel Neafsey, Broad Institute of M.I.T. and Harvard, Cambridge, USA
- Shailja Singh, Jawaharlal Nehru University, Delhi, India
- Arjen Dondorp, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand
- Katherine Walton, School of Earth and Environment, University of Manchester, Manchester, UK
In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. Characterizing the prevalence and genetic diversity of different malaria parasite species and their vectors remains key to understanding the disease. Such ‘complex malaria’ in India impacts its epidemiology, transmission, and clinical manifestation. The aims of the Center for the Study of Complex Malaria (CSCMi) are to develop the knowledge, tools, and evidence-based strategies needed to support Indian malaria intervention and control programs, and to build research capacity in India. CSCMi research comprises two projects: Project 2: Plasmodium vivax Epidemiology and Relapse Genomics, and Project 3: Pathogenesis of Cerebral Malaria. Project 2 aims to address the imbalance of epidemiological and transmission surveillance data for field sites in the state of Meghalaya, with a particular focus on P. vivax. We will undertake cross-sectional, longitudinal, and clinic-based studies in order to describe the burden of symptomatic and asymptomatic malaria, and use novel hand-held real-time genome sequencing devices to categorize recurrences. Our vector studies will include adult surveys to discern biting behavior, insecticide resistance assays, Anopheles population genomics, and pilot projects looking at specific mosquito control methods. Project 3 will use magnetic resonance imaging techniques to study cerebral malaria (CM) pathogenesis at a tertiary hospital in Raurkela, Odisha, and investigate molecular pathogenetic mechanisms of disease. This will include applying advanced machine-learning models of CM disease causation, informed by clinical (neuroimaging, fundus examination, coagulation factors) and laboratory (var gene transcript analysis, plasma biomarkers) investigations. The CSCMi projects will be supported by an Administrative Core and a Scientific Advisory Group. A Data Management Core will build capacity in data management at the sites, and ensure adherence to data standards such as CDISC.
The Center for the Study of Complex Malaria in India is a collaborative scientific research institute comprising US, UK, and Indian malaria experts and dedicated staff at several field sites, working towards the goal of enhancing malaria intervention and control in India.
View Associated sites for the India ICEMR in a larger map.
Map Description: Associated sites for the India ICEMR: West Garo Hills, Jaintia Hills, Rourkela, Madurai
Select Publications from the 2010 Award
- Mohanty S et al. Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain. mSphere. 2017 Jun 7;2(3).
- Uplekar S, et al. Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays. PLoS Negl Trop Dis. 2017 Jan 24;11(1):e0005323.
- Thomas S et al. Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria. Malar J. 2017 Mar 10;16(1):111.
- van Eijk AM et al. The use of mosquito repellents at three sites in India with declining malaria transmission: surveys in the community and clinic. Parasit Vectors. 2016 Jul 27;9(1):418.
- Thomas S et al. Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India. Malar J. 2016 May 11;15(1):274.
- Waite JL et al. Increasing the potential for malaria elimination by targeting zoophilic vectors. Sci Rep. 2017 Jan 16;7:40551.
- Hupalo DN et al. Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nat Genet. 2016 Aug;48(8):953-8.
- Rao PN et al. A Method for Amplicon Deep Sequencing of Drug Resistance Genes in Plasmodium falciparum Clinical Isolates from India. J Clin Microbiol. 2016 Jun;54(6):1500-11.
- van Eijk AM et al. What is the value of reactive case detection in malaria control? A case-study in India and a systematic review. Malar J. 2016 Feb 6;15:67. doi: 10.1186/s12936-016-1120-1.
- Wassmer SC, Carlton JM. Glycophorins, Blood Groups, and Protection from Severe Malaria. Trends Parasitol. 2016 Jan;32(1):5-7.
- Sahu PK et al. Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches. Front Cell Infect Microbiol. 2015 Oct 27;5:75.
- Singh OP et al. L1014F-kdr Mutation in Indian Anopheles subpictus (Diptera: Culicidae) Arising From Two Alternative Transversions in the Voltage-Gated Sodium Channel and a Single PIRA-PCR for Their Detection. J Med Entomol. 2015 Jan;52(1):24-7.
- Mohanty S et al. Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis? Malaria Journal. 2014, 13:276.
- Cator LJ et al. Characterizing microclimate in urban malaria transmission settings: a case study from Chennai, India. Malar J. 2013 Mar 2;12:84.
- Cator LJ et al. Do malaria parasites manipulate mosquitoes? Trends Parasitol. 2012 Nov;28(11):466-70.
- Neafsey DE et al. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat Genet. 2012 Sep;44(9):1046-50.
Featured Research from the 2010 Award
- Gene Sequences Reveal Global Variations in Malaria Parasites
- Understanding How Temperature Can Impact the Intensity of Malaria Transmission
- Environmental Temperature Is an Important Driver of Malaria Transmission Dynamics
- First Plasmodium vivax and Plasmodium falciparum Whole Genome Assemblies From India