India ICEMR

Center for the Study of Complex Malaria in India

Principal Investigator: Jane Carlton, Ph.D.
Lead Institution: New York University, New York
Award date: 2010; renewed in 2017

 

Jane Carlton, Ph.D.

Jane Carlton, Ph.D.

Collaborators

  • Sam Wassmer, London School of Hygiene and Tropical Medicine, London, UK
  • Kishore Mahanta, Ispat General Hospital, Rourkela, India
  • Joe Smith, Center for Infectious Disease Research, Seattle, USA
  • Sandra Albert, Indian Institute of Public Health, Shilong, India
  • Aparup Das, Centre for Research in Medical Entomology, Madurai, India
  • Daniel Neafsey, Broad Institute of M.I.T. and Harvard, Cambridge, USA
  • Shailja Shah, Jawaharlal Nehru University, Delhi, India
  • Arjen Dondorp, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand
  • Katherine Walton, School of Earth and Environment, University of Manchester, Manchester, UK

Research Areas

In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. Characterizing the prevalence and genetic diversity of different malaria parasite species and their vectors remains key to understanding the disease. Such ‘complex malaria’ in India impacts its epidemiology, transmission, and clinical manifestation. The aims of the Center for the Study of Complex Malaria (CSCMi) are to develop the knowledge, tools, and evidence-based strategies needed to support Indian malaria intervention and control programs, and to build research capacity in India. CSCMi research comprises two projects: Project 2: Plasmodium vivax Epidemiology and Relapse Genomics, and Project 3: Pathogenesis of Cerebral Malaria. Project 2 aims to address the imbalance of epidemiological and transmission surveillance data for field sites in the state of Meghalaya, with a particular focus on P. vivax. We will undertake cross-sectional, longitudinal, and clinic-based studies in order to describe the burden of symptomatic and asymptomatic malaria, and use novel hand-held real-time genome sequencing devices to categorize recurrences. Our vector studies will include adult surveys to discern biting behavior, insecticide resistance assays, Anopheles population genomics, and pilot projects looking at specific mosquito control methods. Project 3 will use magnetic resonance imaging techniques to study cerebral malaria (CM) pathogenesis at a tertiary hospital in Raurkela, Odisha, and investigate molecular pathogenetic mechanisms of disease. This will include applying advanced machine-learning models of CM disease causation, informed by clinical (neuroimaging, fundus examination, coagulation factors) and laboratory (var gene transcript analysis, plasma biomarkers) investigations. The CSCMi projects will be supported by an Administrative Core and a Scientific Advisory Group. A Data Management Core will build capacity in data management at the sites, and ensure adherence to data standards such as CDISC.

Regional Impact

The Center for the Study of Complex Malaria in India is a collaborative scientific research institute comprising US, UK, and Indian malaria experts and dedicated staff at several field sites, working towards the goal of enhancing malaria intervention and control in India.

View Associated sites for the India ICEMR in a larger map.

Map Description: Associated sites for the India ICEMR: West Garo Hills, Jaintia Hills, Rourkela, Madurai

Select Publications from the 2010 Award

Featured Research from the 2010 Award

Content last reviewed on July 22, 2017