The Intransigence of Malaria in Malawi: Understanding Hidden Reservoirs, Successful Vectors and Prevention Failures
Co-Principal Investigators: Terrie Taylor, D.O. and Don Mathanga, M.D., M.P.H.
Lead Institution: Michigan State University, East Lansing
Award date: original award in 2010; renewed in 2017
- Miriam Laufer, Division of Malaria Research, Institute of Global Health, University of Maryland School of Medicine
- Don Mathanga, Malaria Alert Centre, University of Malawi College of Medicine
- Karl Seydel, College of Osteopathic Medicine, Michigan State University
- University of Malawi College of Medicine, Blantyre, Malawi
- University of Maryland School of Medicine, Baltimore MD
- University of Michigan, Ann Arbor MI
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi
The primary objectives of research supported by the Malawi ICEMR are to identify, understand, and evaluate interventions that target the determinants of malaria disease. The Center aims to identify reasons why malaria in Malawi has remained resistant to usual control measures. Researchers will accomplish these objectives by systematically surveying populations of vectors, hosts, and parasites using newly developed molecular and genomic tools in conjunction with well-established epidemiologic approaches.
By identifying the contributions made by the parasite, the human host, and the mosquito vector to the incidence and prevalence of malaria disease in diverse eco-geographic settings in Malawi, the research team hopes to tailor prevention and control strategies to specific seasons (such as dry versus rainy climates) and locales (highland and lowland, urban and rural). The team will also determine the critical parameters required for monitoring the impact of such strategies.
View Associated sites for the Malawi ICEMR in a larger map
Map description: Associated sites for the Malawi ICEMR—Blantyre, Chikhwawa, Karonga, Phalombe
Select Publications from the 2010 Award
- Walldorf JA et al. School-Age Children Are a Reservoir of Malaria Infection in Malawi. PLoS One 2014;19(7):e0134061.
- Sisya TJ et al. Subtle changes in Plasmodium falciparum infection complexity following enhanced intervention in Malawi. Acta Trop. 2015;142:108-14.
- Artimovich E et al. Persistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in Malawi. J Infect Dis. 2015;212(5):694-701.
- Artimovich E et al. The effect of local variation in malaria transmission on the prevalence of sulfadoxine-pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi. Malar J. 2015;14(1):387.
- Wilson ML et al. Malaria elimination in Malawi: research needs in highly endemic, poverty-stricken contexts. Acta Tropica. 2012 Mar;121(3):218-26. doi: 10.1016/j.actatropica.2011.11.002. Epub 2011 Nov 15.
- Mathanga DP et al. Malaria control in Malawi: current status and directions for the future. Acta Tropica. 2012 Mar;121(3):212-7. doi: 10.1016/j.actatropica.2011.06.017. Epub 2011 Jul 8.
- Conn JE et al. Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies. Am J Trop Med Hyg. 2015 Aug 10. pii: 15-0009.
- Wassmer SC et al. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015 Aug 10. pii: 14-0841.
- Wilson ML et al. Urban Malaria: Understanding its Epidemiology, Ecology, and Transmission Across Seven Diverse ICEMR Network Sites. Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):110-23. PMID:26259941.
- Buchwald AG et al. Bed net use among school-aged children after a universal bed net campaign in Malawi. Malar J. 2016 Feb 29;15(1):127. PMID: 26928321.
- Coalson JE et al. High prevalence of Plasmodium falciparum gametocyte infections in school-age children using molecular detection: patterns and predictors of risk from a cross-sectional study in southern Malawi. Malar J 2016;1591):527. PMID 27809907.
- Mathanga DP et al. Patterns and determinants of malaria risk in urban and peri-urban areas of Blantyre, Malawi. Malar J. 2016 Dec 8;15(1):590. PMID: 27931234.
- Buchwald AG et al. Insecticide-treated net effectiveness at preventing Plasmodium falciparum infection varies by age and season. Malar J. 2017 Jan 17;16(1):32. doi:10.1186/s12936-017-1686-2. PubMed PMID: 28095916; PubMed Central PMCID:PMC5240228.