Resources for Researchers

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Division of Allergy, Immunology, and Transplantation (DAIT)
Immune System

7 Results

The Immcantation framework is developed as a start-to-finish analytical ecosystem for large-scale characterization of B cell receptor (BCR) and T cell receptor (TCR) repertoires from high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) datasets.

ImmPort is a Web portal that contains data from NIAID-funded immunology studies, including basic research and clinical trials. The portal provides online tools that allow users to analyze the data and visualize the results.

The ImmuneSpace database is currently composed of 21 studies covering 10 types of assays and 2,500 total participants. Gene Expression, Flow Cytometry, and CyTOF are among the included assay types; participants include children, adults, and elderly after vaccination or infection, as well as healthy controls.

The Primary Immunodeficiency (PI) Diseases Registry collects validated data on all PI diagnoses from patients who give Informed Consent. The de-identified data in the registry is freely disseminated to those with research questions about PI diseases.

This Gene Set Enrichment-type test designed for analysis of microarray and RNASeq data is designed to provide a faster, more accurate, and easier to understand test for gene expression studies. QuSAGE extends previous methods with a complete probability density function (PDF). From this PDF, P values and confidence intervals can be easily extracted.

TrialShare is a transformative approach to data-sharing that enables clinical trial transparency. TrialShare provides clinical trial investigators the unprecedented ability to access de-identified study data, review published analysis methods, and perform real-time, interactive graphical analyses in collaboration with other researchers.

This core serves as a national resource following the specific priorities of the NIAID Radiation and Nuclear Countermeasures Program.  Since 2007, the focus has been on the long-term care and study of animals surviving high-dose irradiation.