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Developing, characterizing, and refining animal models are key to advancing medical countermeasures for high-consequence pathogens.
The CIBMTR database contains data on outcomes of hematopoietic (blood and bone marrow) cell transplant (HCT) procedures.
This contract provides gap-filling support services for HIV prevention drug developers including academic (investigators), for-profit and not-for-profit small and large companies, and other product innovators (henceforth identified as Sponsors) for the development of HIV non-vaccine biomedical pr
Repository of specimens collected as part of the DAIDS VAX004 Clinical Trial.
The Feasibility of Novel Diagnostics for TB in Endemic Countries (FEND for TB) program supports the evaluation of early-stage diagnostics and novel diagnostic strategies for TB, in TB endemic countries to address an urgent need for improved tuberculosis (TB) diagnostics.
Heterogeneity in Human Immune Cells is a website providing interactive figures (iFigs) for a recent study of protein expression heterogeneity in human immune cells conducted by Dr.
This service can be used to develop and perform a variety of analytical assays to assess the properties of drug substances and their formulations.
This service provides follow-up studies of products which already have been evaluated in a biochemical or cell-based assay and shown to possess an activity profile that warrants further development of the product as an HIV therapeutic.
This service provides evaluation of products in animal efficacy models. A product must demonstrate a potent and selective activity profile in vitro against the HIV strain used in the model prior to its acceptance as a candidate for this service.
This service can be used to provide pharmacokinetic and safety assessments of products in mice, rats, rabbits, dogs, and nonhuman primates.
In vivo imaging is gaining increasing interest for the characterization of infectious diseases, including the ones caused by high-consequence pathogens.
The Immcantation framework is developed as a start-to-finish analytical ecosystem for large-scale characterization of B cell receptor (BCR) and T cell receptor (TCR) repertoires from high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) datasets.
The Multicenter AIDS Cohort Study (MACS) is an ongoing prospective study of the natural and treated histories of HIV-1 infection in homosexual and bisexual men conducted by sites located in Baltimore, Chicago, Pittsburgh and Los Angeles.
Researchers involved with the NIAID Clinical Genomics Program study many diseases of the immune system that are rare and not well understood but often shed light on basic immune function and more common immune disorders.
The pathology and histology laboratories at the Integrated Research Facility at Fort Detrick (IRF‑Frederick) work together to conduct comprehensive postmortem examinations on laboratory animals of a variety of species studied as models for high-consequence emerging human viral infections.
The Chemical Countermeasures Research Program (CCRP) supports the discovery and early development of medical countermeasures (MCMs) to treat the acute and/or long-term chronic toxicities after exposure to highly tox
This Gene Set Enrichment-type test designed for analysis of microarray and RNASeq data is designed to provide a faster, more accurate, and easier to understand test for gene expression studies. QuSAGE extends previous methods with a complete probability density function (PDF).
The Throughput Ranking by Iterative Analysis of Genomic Enrichment (TRIAGE) platform is designed to facilitate prediction, analysis, and hypothesis generation from High-throughput genomic studies such as those done by CRISPR, RNAseq, proteomic, and clinical sequencing studies.
The virology team at the Integrated Research Facility at Fort Detrick (IRF‑Frederick) has extensive expertise working with a range of high‑consequence viral pathogens.