Malaria Evolution in South Asia
Principal Investigator: Pradipsinh Rathod, Ph.D.
Lead Institution: University of Washington, Seattle
Award date: Original award in 2010; renewed in 2017
- Pradipsinh K. Rathod, University of Washington (Epidemiology of Drug Resistance)
- Neena Valecha, National Institute of Malaria Research (Transmission -Vector Parasite Compatibility)
- Manoj Duraisingh, Harvard T. H. Chan School of Public Health (Pathogenesis & Infection)
- ACIST Consulting (Thane, Maharashtra)
- Agartala Government Medical College (Agartala, Tripura)
- Assam Medical College (Dibrugarh, Assam)
- Goa Medical College (Bambolim, Goa)
- Indian Institute of Technology – Bombay (Mumbai, Maharashtra)
- Ispat General Hospital (Rourkela, Orissa)
- King Edward Memorial Hospital (Mumbai, Maharashtra)
- Krishi Gram Vikas Kendra (Ranchi, Jharkhand)
- Model Rural Health Research Unit (Agartala, Tripura)
- National Institute of Malaria Research Field Unit (Panaji, Goa)
- National Institute of Malaria Research Headquarters (New Delhi)
- Regional Medical Research Centre, NE Region (Diburgarh, Assam)
- Center for Infectious Disease Research (Seattle, WA)
- Fred Hutchinson Cancer Research Center (Seattle, WA)
- Harvard T. H. Chan School of Public Health (Boston, MA)
- Stanford University (Stanford, CA)
The overall goal of the South Asia ICEMR is to understand how the genetic plasticity or adaptability of malaria parasites in the region affects drug resistance, virulence, transmission and human immunity.
Center activities and findings assist in the evaluation of malaria threat levels in India and provide insight into global transmission of virulent malaria through South Asia.
View Associated sites for the South Asia ICEMR in a larger map
Map description: Associated sites in India (Panaji, Goa; Mumbai, Maharashtra; Agartala, Tripura; Dibrugarh, Assam; Rourkela, Orissa; New Delhi)
Select Publications from 2010 Award
- Chery L et al. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malar J. 2016; 15(1): 569. PMID:27884146. PMCID:5123287.
- Kumar S et al. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Mol Biochem Parasitol. 2016; 210(1-2):1-4. PMID: 27457272.
- Lim C et al. Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates. J Infect Dis. 2016; 214 (7):1081-4. PMID: 27432121. PMCID: PMC5021230.
- Bernabeu M et al. Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass. PNAS. 2016; 113(23): E3270-9. PMID: 27185931. PMCID: PMC4988613.
- Kumar A et al. Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission. Malar J. 2016; 15:124. PMID: 26919828. PMCID: PMC4769513.
- White J et al. In vitro adaptations of Plasmodium falciparum reveal variations in cultivability. Malar J. 2016; 15:33. doi: 10.1186/s12936-015-103-0. PMCID: PMC4722725.
- Guler JL et al. Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire beneficial DNA amplifications. PLoS Pathogen. 2013; 9(5):e1003375. PMID: 23717205. PMCID: PMC3662640.
- Kumar A et al. Malaria in South Asia: Prevalence and control. Acta Trop. 2012; 121(3):246-55. PMID: 22248528. PMCID: PMC3808995.
- Kumar A et al. Malaria-attributed death rates in India. Lancet. 2012; 377(9770):991-2; author reply 994-5. PMID: 21420546. PMCID: PMC3883669.