Sub-Saharan Africa International Center of Excellence for Malaria Research

Environmental Modifications in sub-Saharan Africa: Changing Epidemiology, Transmission and Pathogenesis of Plasmodium falciparum and P. vivax

Principal Investigator: Guiyun Yan, Ph.D.
Lead Institution: The University of California, Irvine
Award date: 2017

Guiyun Yan, Ph.D.

Guiyun Yan, Ph.D.


Project Leads

  • Ming-Chieh Lee, University of California, Irvine 
  • Guiyun Yan, University of California, Irvine
  • James Kazura, Case Western Reserve University, Cleveland

Collaborating Institutions

  • Addis Ababa University, Addis Ababa, Ethiopia
  • Burnet Institute, Melbourne, Australia
  • Case Western Reserve University, Cleveland
  • Jimma University, Jimma, Ethiopia
  • Kenya Medical Research Institute, Kismu, Kenya

Research Areas

The overarching goal of this ICEMR project is to assess the impact of human-induced environmental modifications such as dam construction, irrigation and shifting agricultural practices on the epidemiology, transmission, pathogenesis and immunology of Plasmodium falciparum and P. vivax malaria in highly populated Kenya and Ethiopia where major investments in water resource development projects are taking place.

Regional Impact

In the past decade, sub-Saharan African countries have experienced a new era of large dam constructions and expansion of irrigated agricultural farms to resolve famine and food shortage. These environmental changes may have unforeseen ecologic consequences that adversely affect human health. Knowledge gained from this ICEMR is important to malaria control, not only for the two study countries studied, but also to other regions of Africa prone to drought, famine, and large scale human population movement.

View Associated sites for the Sub-Saharan Africa ICEMR in a larger map.

Map description: Associated sites in Ethiopia (Gambella Rice Irrigation area, Ajro Dam site, Jimma Zone) and Kenya (Chulaimbo site, Kendu Bay)

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