Center of Excellence for Systems Modeling of Infection and Immunity Across Biological Scales, funded by the National Institute of Allergy and Infectious Diseases, seeks to accelerate the utility of computational models across allergic, infectious, and immunological diseases. This interdisciplinary effort will create sophisticated multiscale computer models to enhance the understanding of disease development and transmission to support innovative treatment methods by accounting for variations among individuals and communities. Additionally, the Center will engage with the broader modeling community to host training and model sharing activities.
Programs
Currently Funded: Multiscale Immune Systems Modeling (MISM)
In response to RFA-AI-23-077, the MISM Center of Excellence (CoE) will coordinate research applying computational modeling and other IID modeling across biological scales. The CoE will accelerate multi-scale model development, sharing and re-use, and support collaboration to benefit the allergic, immunologic, and infectious disease research community.
Duke University School of Medicine; Center of Excellence for Multiscale Immune Systems Modeling (MISM)
- Contact PI: Cliburn C. Chan, MBBS, Ph.D., Keith Reeves, Ph.D.
- Project 1: Rohit Singh, Ph.D. Integrating Atomic-Scale Antigen Modeling and Repertoire-Scale Protein Language Models
- Project 2: Micah A. Luftig, Ph.D. Bridging Cell and Organism scales to Model Viral, Cell, and Microenvironmental Determinants of Infection Outcome
- Project 3: Bruce Rogers, Ph.D. Immune Response, Transmission Model, and Contact Network Determinants of Disease Spread
- Administrative Core: Cliburn C. Chan, Ph.D.
- Community Development and Education Core: Gina-Maria Pomann, Ph.D.
- Model and Data Sharing Core: Nrupen Bhavsar, Ph.D.