Program for Resistance, Immunology, Surveillance, and Modeling of Malaria in Uganda
Principal Investigator: Grant Dorsey, M.D.
Lead Institution: University of California, San Francisco
- Surveillance: Moses R. Kamya, Infectious Disease Research Collaboration (IDRC), Makerere University Faculty of Medicine; Sarah Staedke, London School of Hygiene and Tropical Medicine
- Immunology: Harriet Mayanja-Kizza, IDRC, Makerere University Faculty of Medicine; Chris Drakeley, London School of Hygiene and Tropical Medicine
- Resistance: Samuel Nsobya, IDRC, Makerere University Faculty of Medicine; Philip Rosenthal, University of California, San Francisco
- IDRC, Makerere University Faculty of Medicine, Kampala, Uganda
- Johns Hopkins University
- Liverpool School of Tropical Medicine
- London School of Hygiene and Tropical Medicine
- University of Durham
- University of Southampton
The overall goal of the Uganda ICEMR will be to perform comprehensive surveillance studies to improve understanding of malaria and measure the impact of population-level control interventions.
Studies will be conducted in six sentinel sites, ranging from areas of relatively low transmission intensity to areas with some of the highest transmission intensities recorded in the world.
Uganda provides an ideal environment for this program as malaria covers a wide range of epidemiological settings in the country. Researchers hope to use the varied settings to evaluate intervention strategies and assess optimal control methods.
Map description: Associated sites for the Uganda ICEMR: Kabale District, Mubende District, Apac District, Kanungu District, Jinja District, Tororo District
- Kigozi SP et al. Associations between urbanicity and malaria at local scales in Uganda. Malaria Journal. 2015, 14:374 DOI: 10.1186/s12936-015-0865-2
- Boyle MJ et al. Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria. PLoS Pathog. 2015;11(7):e1005041. PMID: 26182204; PMCID PMC4504515
- Helb D et al. Novel serologic biomarkers provide accurate estimates of recent P. falciparum exposure for individuals and communities. Proc Natl Acad Sci U S A. 2015;112(32):e4438-47. PMID: 26216993; PMCID PMC4538641
- Weetman D et al. Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae. Mol Ecol. 2015;24(11):2656-72. PMID: 25992620; PMCID PMC4437786
- Sullivan RT et al. FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. PLoS Pathog. 2015;11(5):e1004894. PMID: 25993340; PMCID PMC4438005
- Tumwebaze P et al. Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from Ugandan children. Antimicrob Agents Chemother. 2015;59(6):3018-30. PMID:25753626; PMCID PMC4432194
- Yeka A et al. Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda. PLoS One. 2015;10(3):e0118901. PMID 25768015; PMCID PMC4358889
- Boyle MJ et al. The effector phenotype of malaria-specific CD4 T cells is influenced by both age and transmission intensity in naturally exposed populations. J Infect Dis. 2015;212(3):416-25. PMID 25646355; PMCID PMC4539911
- Kamya MR et al. Malaria Transmission, Infection and Disease at Three Sites with Varied Transmission Intensity in Uganda: Implications for Malaria Control. Am J Trop Med Hyg. 2015;92(5):903-12. PMID 25778501; PMCID PMC4426576
- Wanzira H et al. Mind the gap: house structure and the risk of malaria in Uganda. PLoS One. 2015 ;10(1):e0117396. PMID 25635688; PMCID PMC4311957
- Achieving the Stability of Malaria Elimination
- Building Models to Understand Human Mobility and Malaria Transmission
- All Featured Fesearch From the ICEMR Program