Multidisciplinary Research for Malaria Control and Prevention in West Africa
Principal Investigator: Seydou Doumbia, M.D., Ph.D.
Lead Institution: University of Sciences, Techniques, and Technology of Bamako, Mali
Award date: 2017
- Nafomon Sogoba, University of Sciences, Techniques, and Technology of Bamako
- Mahamadou Diakite, University of Sciences, Techniques, and Technology of Bamako
- Sekou Fantamad Traore, University of Sciences, Techniques, and Technology of Bamako
- Tulane University, New Orleans, LA
- University of Georgia, Athens, GA
- University of Miami, Miami, FLA
- London School of Hygiene and Tropical Medicine, London, UK
- University of Copenhagen, Denmark
- Wellcome Trust Sanger Institute, Hinxton Cambridge, UK
- Malaria Immunology Section, Laboratory of Malaria and Vector Research, NIAID
The overall goal of this ICEMR is to understand the variable effectiveness of current malaria control interventions in different ecological settings of West Africa. This goal will be accomplished by performing field and laboratory studies of the epidemiology, entomology (transmission), immunology and pathogenesis of malaria to characterize and understand:
- The heterogeneity of malaria infection, disease and transmission
- The effects of control strategies on malaria transmission and pathogenesis
- The major obstacles to improving malaria control and potentially eliminating malaria, including drug and insecticide resistance
Sub-Saharan Africa continues to carry a disproportionately high share of the global malaria burden. of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. This Center proposes to link the different aspects of malaria transmission and disease into a unified whole, adding the ability to distinguish the contributions of different malaria control interventions on parasite population and immune responses as well as the seasonal and geographical distribution of anopheline mosquitoes. Understanding the factors relating entomological and epidemiological patterns of transmission will provide more definitive guidelines for malaria control efforts in Mali and in West Africa.
View Associated sites for the Mali ICEMR in a larger map
Map description: Associated sites for the Mali ICEMR: Dangassa, Dioro, Sirakorola
- Keating J, Krogstad DJ, Eisele TP. Malaria elimination on Hispaniola. The Lancet. 10.5 (2010): 291-293.
- Doumbia SO et al. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Tropica. 2012 Mar;121(3):175-83. doi: 10.1016/j.actatropica.2011.11.009. Epub 2011 Nov 28
- Ceesay SJ et al. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Tropica. 2012 Mar;121(3):166-74. doi: 10.1016/j.actatropica.2011.11.005. Epub 2011 Nov 19.
- Volkman SK et al. Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Tropica. 2012 Mar;121(3):324-32. doi: 10.1016/j.actatropica.2011.12.002. Epub 2011 Dec 13.