Study of Antibiotic-Induced Vaginal Yeast Infections in Healthy Women

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We need healthy women to volunteer for a new research study at the National Institutes of Health

Vaginal yeast infection, or vulvovaginal candidiasis, is a common cause of vaginal irritation. Approximately 75 percent of all women will get a yeast infection in their lifetime. This study is trying to determine why taking antibiotics sometimes increases a woman’s risk of getting a yeast infection.

Who can participate?

You may be eligible if you are

  • Female
  • 18 to 40 years old
  • Healthy
  • Using an oral contraceptive

What does the study involve?

Volunteers will visit the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, for a screening visit. Eligible participants will have seven or more visits over three months and will keep a daily diary for the first month. Most participants will receive a ten-day course of a common antibiotic, amoxicillin. It is anticipated that some women will develop a vaginal yeast infection while others will not, allowing researchers to study how amoxicillin affects the microorganisms that normally live in the vagina and how these changes are associated with getting a vaginal yeast infection.

Where is the study taking place?

The study is being conducted at the NIH Warren Grant Magnuson Clinical Center in Bethesda. The NIH campus is accessible by car and public transportation.

How much does it cost?

There is no charge to participate in this research study. All study-related medical care and procedures are provided free of charge.

Will I receive payment of some kind?

All study participants will receive financial compensation.

How do I find out more or volunteer?

Visit for details.

Contact Information

Office of Patient Recruitment, NIH Clinical Center
Toll Free: 1-877-999-5557 (reference 13-I-0181)
TTY: 1-866-411-1010 Se habla español.
Office hours: 8:00 a.m.-3:30 p.m. Eastern Time

Participating in Research

Watch a series of short informational videos about participating in clinical trials. These videos are intended to help potential participants understand how research works, what questions they should consider asking, and things to think about when deciding whether or not to participate in a study.

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