Discovered in the Zika forest, Uganda, in 1947, Zika virus is a member of the flavivirus family. Other flaviviruses include those that cause dengue, yellow fever, and West Nile fever. Like its relatives, Zika virus is primarily transmitted to humans through the bite of infected Aedes aegypti mosquitoes. Zika virus can be transmitted from an infected pregnant woman to her baby during pregnancy and can result in serious birth defects, including microcephaly. Less commonly, the virus can be spread through intercourse or blood transfusion. Most people who become infected with Zika virus do not become sick. For the 20 percent of people who do develop symptoms, the illness is generally mild and includes fever, rash, joint pain and conjunctivitis (red eyes). Illness lasts several days to a week. In non-pregnant people, the virus is generally eliminated from the body after a few weeks although it may remain longer in semen.
Why Is the Study of Zika Virus a Priority for NIAID?
In May 2015, the Pan American Health Organization issued an alert regarding the first confirmed Zika virus infection in Brazil. Since that time, Brazil and other countries and territories in Central and South America, as well as the Caribbean (including Puerto Rico and the U.S. Virgin Islands) have experienced ongoing Zika virus transmission. The first cases of locally transmitted Zika virus in the continental United States were confirmed in Florida in July 2016, followed by Texas in November 2016. The majority of Zika cases in the continental U.S. have been among people who travelled to affected countries. Read more about why studying Zika virus is a priority for NIAID.
How Is NIAID Addressing This Critical Topic?
NIAID is working with its partners in government, academia, and the pharmaceutical and biotechnology industries to better understand Zika virus, the disease it causes, and ways to combat it. Specifically, NIAID is accelerating research in areas such as the natural history of the disease, basic research on the Zika virus, how it causes disease (called pathogenesis), diagnostics to rapidly determine if someone is or has been infected with Zika and to distinguish from other flaviviruses, as well as treatments and vaccines. Read more about how NIAID is addressing Zika virus.
NIAID research helps us learn more about the Zika virus to help those affected. The National Library of Medicine offers a Zika Virus Health Information Resource Guide for more information on where the current risks are and other research initiatives world wide.
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Single-Dose, Investigational Zika Vaccine Protects Mice, Monkeys, October 19, 2017