Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

Official Study Title: Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons (COVIDARC19)

COVID-19 virus infection can occur in persons without signs or symptoms of infection, to those with mild or moderate signs of infection (such as fatigue, muscle aches, headache, loss of smell or taste). In the worse situation, it can become a life- threatening infection that causes damage to different organs in the body.  We want to understand how the body's immune system helps to control the infection. In addition, we want to understand how different organs of the body (such as the lungs, heart, brain, and kidneys) respond to the infection from its early appearance to recovery, and whether there are any long-term effects of the infection on the organs of the body. We hope that this information may tell us when to use medications to decrease inflammation and how this may affect getting rid of (killing) the virus.

What does the study involve?

We will take samples of blood, urine, washings from the lung airways, and in some persons, spinal fluid, to test for the virus and the body's response to the infection. In addition, we want to use different ways to look at the organs of the body (lungs, heart, brain, kidneys) with special radiology tests. These tests include MRI (or magnetic resolution imaging), CT scan (computerized tomography) and ultrasound. 

If you are entering this study at the beginning of your infection with the COVID-19 virus, we will provide you with outpatient or hospital care that is appropriate for your infection. If there are other studies that are available at NIH for the treatment of COVID-19 infection, you may be eligible to participate in these studies while participating in this research study. Following your acute illness, we will ask you to return during your recovery (after 1 to 3 months) and convalescence (3 to 12 months) to perform follow-up studies.

If you are entering this study after you have recovered from COVID-19 infection, we may have you stay in the hospital for a brief period (1–2 days) in order to perform the tests to study how the infection has affected your body. If you need to return to the hospital for these tests, we will pay for your transportation.

Is Compensation Provided?

Volunteers will be compensated.

Who can participate?

  • You are between 18 and 80 years old 
  • You have had a positive COVID-19 test within 14-28 days after first experiencing symptoms
  • You agree to stay as an inpatient in the NIH Clinical Center, if appropriate
  • You allow the NIH to store blood and tissue samples for future research
  • You live within 50 miles of the NIH, and are able to travel to the NIH in Bethesda, Maryland

Where is it taking place?

The NIH in Bethesda, Maryland, and MedStar Health Research Institute/MedStar Washington Hospital Center in Washington, D.C.

Visit for details.

Contact Information

Volunteer or get more information
Toll free: 1-800-411-1222
TTY: 1-866-411-1010
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