Eosinophilic Esophagitis Studies

Credit: NIAID

Eosinophilic esophagitis, or EoE, is a chronic disease that can be associated with food allergies. EoE is characterized by immune cells called eosinophils building up in the esophagus. This build up may cause polyps, tissue break down, inflammation, and ulcers. NIAID’s research on EoE and other disorders related to food allergy may provide insight into new treatments and prevention options.

Current Clinical Research Studies Seeking Volunteers

The following are selected clinical trials supported by NIAID and investigating various aspects related to EoE. The links lead to full study descriptions, eligibility criteria and contact information.

Use of Unsedated Transnasal Esophagoscopy to Monitor Dietary Management of EoE in Children (CEGIR 7808) (NCT03342391)

This study examines how long it takes EoE to come back after you start a new food and tests the effectiveness and safety of using unsedated Transnasal Esophagoscopy as a means of monitoring the return of EoE. The study is enrolling people ages 8 years to 22 years.

On Open-Label Trial of Losartan Potassium in Participants with EoE (NCT03029091)

The purpose of this research study is to test the safety and effectiveness of Losartan potassium in treating EoE. The study is enrolling people ages 5 years to 25 years. Losartan is a drug that is approved by the United States Food and Drug Administration for use in adults and children older than 6 years of age who have high blood pressure. This medication has not been studied in people with EoE.

Six Food vs. One Food Eosinophilic Esophagitis Diet Study (SOFEED) (NCT02778867)

The purpose of this study is to test and compare the effectiveness of two elimination diets in people ages 18 years to 60 years who have been diagnosed with EoE, eosinophilic colitis, or eosinophilic gastritis.

Effect of Elemental Diet on Adult Patients with Eosinphilic Gastroenteritis (CEGIR 7809) (NCT03320369)

The purpose of this study is to investigate the effect of an elemental diet on adult patients between the ages of 18 and 65 years with eosinophilic gastroenteritis.

Natural History and Genetics of Food Allergy and Related Conditions (NCT02504853)

The objective of this study is to learn more about the causes and effects of food allergy and related conditions. People ages 2 to 99 years who have food allergy and/or a related genetic or other condition may be eligible to participate.

Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages (OMEGA) (NCT02523118)

The purpose of this study is to learn more about eosinophilic gastrointestinal disorders including eosinophilic esophagitis, eosinophilic gastritis, or eosinophilic colitis. Although effective treatments exist for these diseases, there is no known cure and symptoms and intestinal damage varies from patient to patient.

Read about NIAID’s research to characterize food allergy and address related disorders.

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