Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up (PECOS)

Boy (8-9) wearing protective face mask - stock photo. Portrait of a little girl wearing protective face mask stock photo.

Boy (8-9) wearing protective face mask - stock photo. Portrait of a little girl wearing protective face mask stock photo.

This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population, including coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C), and characterize the immune response associated with these clinical presentations.

What Does the Study Involve?

This study will establish a cohort of surviving pediatric patients with symptomatic (including COVID-19 and MIS-C) and asymptomatic SARS-CoV-2 infection to study the long-term sequelae of acute infection and the evolution of the immune response over time. Longitudinal follow-up of this cohort will provide important information about clinical sequelae of acute COVID-19 and MIS-C, characteristics of the immune response to SARS-CoV-2, genetic factors associated with long-term outcomes, and the extent and duration of protective immunity.

Who Can Participate?

Participants aged 3 to 21 years with confirmed history of symptomatic SARS CoV-2 infection (including COVID-19), MIS C, or asymptomatic SARS CoV-2 infection (n = up to 1000), as well as healthy contacts (aged ≤21 years; n = up to 1000). Additionally, a parent or guardian of each participant will be enrolled to complete targeted questionnaires (n = up to 2000).

Where Is It Taking Place?

National Institutes of Health (NIH)/ National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland United States 20852 

Is There a Cost?

No

Is Compensation Provided?

 The total amount for completion of all scheduled study visits will be $320 for survivors in the recovery group, $280 for survivors in the convalescent group, and $160 for household contact participants.

Number of Visits Required:

Recovery Group: 8 visits 
Convalescent Group: 6 visits
Healthy Contact: 4 visits

Steps to Participate:

Fill out our interest form on the Formstack website - https://childrensnational.formstack.com/forms/covid_misc_study 
 

Visit ClinicalTrials.gov for details.

Contact Information

Email: niaidpedscovid@niaid.nih.gov

Collaborators:

Gina A. Montealegre Sanchez, MD, MS; Karyl Barron, MD; Roberta DeBiasi, MD

Participating in Research

Watch a series of short informational videos about participating in clinical trials. These videos are intended to help potential participants understand how research works, what questions they should consider asking, and things to think about when deciding whether or not to participate in a study.

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