Systemic Allergic Reactions to SARS-CoV-2 Vaccination

This research is being done to determine whether highly allergic people or people with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely to have an allergic reaction to the new Pfizer-BioNTech and Moderna COVID-19 vaccines than other people. We would also like to understand why some people have allergic reactions to these vaccines.

What does the study involve?

Participation could be as short as 29 days or as long as 64 days.

If you join the study, you will complete 2 to 4 clinic visits and have 3 to 4 phone calls over a period of 29 to 43 days, depending on which vaccine you receive and whether you get the additional placebo dose.

You will receive either the Pfizer-BioNTech or Moderna COVID-19 vaccine. Each vaccine requires two doses. If you don’t have a reaction to the first vaccine dose, you will receive the second vaccine dose. Some subjects may also receive a dose of placebo (salt water). You will receive three shots total, if you receive a placebo shot.

Who can participate?

Individuals who are 18 to 69 years of age and either have a history of serious allergic reaction, have a mast cell disorder, or have no allergies at all.

Where is it taking place?

Up to 40 sites across the U.S.

Is compensation provided?

You will receive $50 for each study visit and compensation for minor expenses, such as travel or parking costs.

Number of visits?

2 to 4

Participating in Research

Watch a series of short informational videos about participating in clinical trials. These videos are intended to help potential participants understand how research works, what questions they should consider asking, and things to think about when deciding whether or not to participate in a study.

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