Genomic analysis of progenitors in viral infection implicates glucocorticoids as suppressors of plasmacytoid dendritic cell generation

Using multi-omics analysis, the authors show that viral infection push dendritic cell progenitors away from Plasmacytoid Dendritic cell development and this seems to be influenced by Glucocorticoids. Virally infected mice lacking adrenal glands had significantly lower levels of Plasmacytoid Dendritic cells than did infected mice with adrenal glands and the corresponding glucocorticoids.